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Experimental Study of Effects and Mecha-nisms of Fufangbiejiaruanganfang Drug Serum on Proliferation and Activation of Rat Hepatic Stellate Cell Cultured with KC Condition Medium

Author: JiaWenZuo
Tutor: GuoShunGen
School: Beijing University of Traditional Chinese Medicine
Course: Chinese and Western medicine combined with the basis
Keywords: hepatic fibrosis hepatic stellate cell(HSC) kupffer cells conditioned medium(KCCM) activation proliferation α- smooth muscle actin transforming growth factor-beta1 fufangbiejiaruanganfang
CLC: R285
Type: Master's thesis
Year: 2006
Downloads: 94
Quote: 0
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Abstract


Objectivethe activation of hepatic stellate cell is regulated by many kinds of cells and cytokines, which includes hepatic cells、kupffer cells、hepatic sinusoidal endothelial cells.In KC condition medium(kccm), KC serects lot of cytokines can promote HSC to active.This experiment is to discuss the reflection beween KCCM and HSC, as well as the reflection of proliferation and activation of HSC, and the intervenient function of fufangbiejiaruanganfang drug serum, in order to supply the experiment base for prevention and treatment of liver fibrosis by Traditional Chinese and Western Medicine combination.DrugAt present, many studies indicate tradition Chinese medicine against hepatic fibrosis has better clinical effects and lower side effects. Our study investigated the inhibitory mechanisms of fufangbiejiaruanganfan against hepatic fibrosis. The prescription of fufangbiejiaruanganfan include biejia, danggui, dangshen; et al. The important fuction of fufangbiejiaruanganfang is that can activate blood circulation to dissipate blood stases.Method1. Buliding model : rat model of liver fibrosis was induced by celiac injection of a mixture of CCL4 liquid which included CCL4 , peanut oil(6:1), three times a week , totalled six weeks.

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CLC: > Medicine, health > Chinese Medicine > Of Pharmacy > Pharmacology
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