Dissertation > Excellent graduate degree dissertation topics show

The Pathological Mechanism and the Research of Operation in the Patients with Persistent Diabetic Macular Edema

Author: GuoCongRong
Tutor: MaJingXue；LiuJianZong；ShiFeng；YeCunXi
School: Hebei Medical University
Course: Ophthalmology
Keywords: diabetic retinopathy diabetic macular edema vitreomacular traction laser photocoagulation pars plana vitrectomy visual function immunohistochemistry transmission electron microscope
CLC: R774.5
Type: Master's thesis
Year: 2002
Downloads: 52
Quote: 0
Read: Download Dissertation

Abstract


Objective: Macular edema (ME) was the most important problem in patients with diabetic retinopathy (DR), and also was the main cause to visual functional lesion in patients with background retinopathy. ME was influenced by many elements, such as breakdown of the blood-retinal inner and outer barriers, and effects of the whole body, and so on. The main treatment to ME was laser photocoagulation (LP). But to some patients with ME, simple LP had no effect on ME, and some patients even got worse. Recently some researchers inferred that the traction of vitreous cortex to macular region may play an important role in this course. So some foreign researchers used pas plana vitrectomy (PPV) to treat these patients, but no positive reports about it were found at interior of country. In this study, some patients were treated with PPV. They had experienced LP, and after 6 months, their ME made no progress, or even got worse, The preoperative and postoperative visual activity, level of edema, PIoo latency, the mean light sensitivity at central 30’ , and FAZ were determined in this study to make sure . Whether there was significant difference between the preoperative andpostoperative levels. Research of immunohistochemistry and electron microscope were also studied. The objective of this study were: 1. To find histochemistric evidence to prove that there was continuous macular traction in patients with DME. 2. To study the nosogenesis in persistent DME. 3. To evaluate the effect of the operation to patients with DME.Methods:l.In 7 patients (10 eyes) with persistent DME (all these patients were treated with PPV),the preoperative visual activity of lm,3m,6m,9m,and fluorescein angiography (FA) were determined. The same targets were also determined postoperatively.2.The preoperative and postoperative area of FAZ were determined in these patients. Significance test was used between the preoperative area of FAZ and postoperative area.3.The 3m P-VEP were determined between preoperation and postoperation. The 6m P-VEP were also determined.4.The pre-and postoperative mean light sensitivity at central 30 were determined in these patients. Significance test was used between the preoperative mean light sensitivity at central 30 and the postoperative level.5. The vitreous specimens were treated with HE dying, immunohistochemistry with light microscope and electron microscope . The cells and extracellar stroma were studied by these ways.Results:l.In 3m test ,visual activity increased (2 lines) in 5 eyes after PPV, 3 eyes kept the same (3/10,30%), and visual activity fell (2 lines) in 2 eyes (2/10,20%).In 6m test ,visual activity increased (2 lines) in 5 eyes (5/7,71.43%), 2 eyes kept the same (2/7,28.57%), no one’s visual activity fell (2 lines). There was significant difference between 3m and 6m test.2. There was significant difference between the preoperative 6ME and postoperative 6m ME(P-5.142xl0-15 ).3 .There was significant difference in the 6m area of FAZ between the preoperative and postoperative levels (P=0.0284). There was significance in the 9m area of FAZ between the preoperative and postoperative levels (P=0.029). There was significant difference in the area of FAZ between the patients’ preoperative levels and the normal group (P=0.0004), and there was no significant difference in the 9m area of FAZ between the patients’ postoperative levels and the normal group’s (P=0.0508). The area of FAZ in patients with persistent DME was broader than the area of the normal group.4. There was significant difference in the P100 latency between the preoperative and 3m , 6m postoperative levels (P=0.0099,p=0.0105).5.There was significant difference in the mean light sensitivity at central 30?between preoperative and 6mpostoperative levels (P=0.0049). The postoperative mean light sensitivity at central 30?got better than the preoperative levels.6. Cells were found with light microscope (HE dying) as following: (1) fibroblasts( fusiform cells) (2) neuroglial cells (small, round nucleus,

Related Dissertations

  1. Roles of MMP-7 and Lysozyme in the Pathogenesis of Ulcerative Colitis Induced by DSS in Balb/c Mice,S858.91
  2. The Study of Kisspeptin/GPR54 System on the Reproductive Regulation in the Hen’s Hypothalamus-Pituitary-Ovary Axis,S831
  3. Study on the Digestive Tube During the Embryonic Stage of Gushi Chicken,S831
  4. A Comparative Study of prawns, crabs, Spiroplasma disease immunohistochemistry and pathology,S945
  5. Expression of WW Domain Containing Oxidoreductase Gene in Cholangiocarcinoma and Its Effect on the Biological Behavior of Cancer Cell Line QBC939,R735.8
  6. Expressions of PRL-3 and p27 in Gastric Carcinoma and Their Clinical Significance,R735.2
  7. Expression of hnRNP A2/B1 and p21WAF1 Proteins in Lung Cancer and Their Clinical Significance,R734.2
  8. The Effects of RIP on the Immune Function of Renewal Rats Without Colostrums,S853.7
  9. Study on the Expression and Correlation of Metallothionein and Matrix Metalloproteinase-2 in Non-small Cell Lung Cancer,R734.2
  10. Expression and Their Significance of Apoptosis Regulatory Factors Survivin、XIAP and c-Jun、NF-κB in Epithelial Neoplasm of Ovary,R737.31
  11. Expression and Clinical Significance of Survivin and YAP in Cervical Carcinoma,R737.33
  12. Expression and Clinical Significance of PTEN and Caspase-7 in Gastric Cancer and Precancerous Lesion,R735.2
  13. Cloning and Expression Analysis of NCCRP-1 AND IL-10 Genes in Grass Carp (Ctenopharyngodon Idellus),S917.4
  14. Expression and Antibody Preparation of sglt1 from Cyprinus CarpioL.,S917.4
  15. Study on Therapy and Mechanisms of the Role of Tang Kang in Diabetic Rat and Endothelial Cells,R285.5
  16. The Effect of Hepatic Denervation on Liver Regeneration after Partially Hepatectomy in Rats,R363
  17. Expression and Correlation of Caspase-3 and Cx43 in Myocardial Infarction with Different Narrow Degree Coronary Artery,R542.22
  18. The Expression and Relationships of Bmi-1 and c-myc in Diffuse Large B-cell Lymphoma Tissues,R733.1
  19. Expression of Caspase-4 and Caspase-3 Gene Related Apoptosis in Pathological Changes of Sternocleidomastoid of Congenital Muscular Torticollis and Four Years Clinical Followed-up for Opereated Patients,R726.8
  20. The Feasibility of the Immunohistochemistry Classification to Predicting Prognosis in Breast Cancer,R737.9
  21. Expression Characteristics and Clinical Significance of RECK in Cervical Cancer,R737.33

CLC: > Medicine, health > Ophthalmology > Retina and optic nerve diseases > Macula,the central fossa disease
© 2012 www.DissertationTopic.Net  Mobile