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Treatment with Atorvastatin Suppresses the Development of Experimental Abdominal Aortic Aneurysms in Rat

Author: XuWenPing
Tutor: QiuJian
School: First Military Medical University
Course: Department of Cardiology
Keywords: Abdominal aortic aneurysms Nuclear factor-κB Peroxisome proliferators activated receptorsγ Atorvastatin Inflammation Animal model Matrix metalloproteinase
CLC: R96
Type: Master's thesis
Year: 2006
Downloads: 32
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Abstract

Objective: Abdominal aortic aneurysms (AAAs) are associated with atherosclerosis, chronic inflammation, and matrix metalloproteinase (MMP)-mediated connective tissue destruction. Inflammation and matrix degradation, contribute to the progression of abdominal aortic aneurysm (AAA). Importantly, the inflammation is regulated by the transcription factor nuclear factor-κB (NF-κB) , whereas the destruction and degradation of elastin fibers by matrix metalloproteinases (MMP) are regulated by its .Study has been suggested that many of these anti-inflammatory effects of PPARs may be due to inhibition of the NF-κB signaling pathway. Presently no reports showed that the NF-κB and the PPARγ could be an impact on the development and progression of AAAs. The occurrence of these pathophysiological processes within both AAAs and vulnerable atherosclerotic plaques suggests that these conditions likely share many potential targets for pharmacologic therapy. Because statins exert antiinflammatory activities independent of their lipid-lowering effects, these agents may help suppress aneurysmal degeneration and suppressed the development of the AAA.Our object is to determine if the NF-κB and the PPARγ could be an impact on the development and progression of AAAs. We observed if treatment with

Treatment with Atorvastatin Suppresses the Development of Experimental Abdominal Aortic Aneurysms in Rat

Abstract

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