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Effect of LipoPGE1 on Endothelin and Calcitinin Gene Related Peptide in Patients with Acute Cerebral Infarction

Author: ZhangXiaoHong
Tutor: ZhangChaoDong
School: China Medical University
Course: Of neural science
Keywords: The alprostadil fat microglobulin carrier injection Cerebral infarction Endothelin Calcitonin gene-related peptide
CLC: R743.3
Type: Master's thesis
Year: 2006
Downloads: 125
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Abstract


The alprostadil Lipo-injection on acute cerebral infarction endothelin and calcitonin gene-related peptide Preface prostaglandin E1, also known as prostaglandin Seoul, it is a Eicosane class of compounds from two high-r - linoleic acid (DHLA), is one of the the important endogenous physiologically active substance in body, it has a dilation of blood vessels. Buck. Inhibition of platelet aggregation. Microcirculation. Anti-atherogenic and immune regulation, and a variety of physiological and pharmacological effects. Wu Ping LipoPGE1 Clinical Observation of 33 cases of acute cerebral infarction within 3 days of onset of cerebral infarction markedly effective rate was 78.8%, total effective rate was 97%. In this study, radioimmunoassay understanding of cerebral infarction after LipoPGE1 ET and cGPR expression, and to explore its pharmacological effects, provide a new theoretical basis for LipoPGE1 treatment of cerebral infarction. Body plasma ET levels in acute cerebral infarction, cerebral infarction change local vascular ischemia and hypoxia, vascular endothelial cell damage, thereby stimulating endothelial cells synthesize and secrete ET increased stress response in the body can cause cerebral infarction catecholamines and angiotensin secretion increased due to increased release of ET, the vascular perfusion depression, tension release surface of endothelial cells, increased release of ET, a high level of ET can induce cerebral vascular and meningeal blood vessels continued strong contraction, causing brain tissue ischemia and hypoxia, further aggravate cerebral vascular endothelial injury, creating a vicious cycle therefore ET involved in the change process of cerebral infarction, ET can be used as one of the important indicators for monitoring of cerebral infarction. ET is the knowledge of the role of the strongest long-acting vasoconstrictor the corresponding antagonistic cGRP body found so far the strongest vasodilator vasodilator mechanism of cGRP is not very clear now that the mechanism may be ① CGRP vascular direct role. C-AMP mediated the ② intracellular second messenger. (3) through the activation of smooth muscle K -ATP channel. The ④ neuron N-type and P-type voltage-sensitive channel with cGRP vasodilation. ⑤ may maintain intracellular Ca 2 stable. ET and CGRP is widely distributed in the central nervous and cardiovascular systems, two substances are antagonistic to each other, they are the most studied in recent years, biologically active substances, the study further elaborated from the ET and CGRP LipoPGE1 cerebral infarction and protection effect.

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CLC: > Medicine, health > Neurology and psychiatry > Neurology > Cerebrovascular disease > Acute cerebrovascular disease ( stroke)
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