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Schistosomiasis is a serious hazard to human health and the impact of socio-economic development one of the major infectious diseases . Chemotherapy is one of the main methods of controlling schistosomiasis transmission . The artesunate China has developed a new type of anti - Schistosoma japonicum drugs . The paper experimentally observed sensitivity of different developmental stages of Schistosoma japonicum artesunate vivo T lymphocyte subsets of the infected host and artesunate , artesunate ester and praziquantel combination therapy the effect of treatment of schistosomiasis japonica designed to provide experimental evidence for insect resistance to further explore artesunate and optimize the use of the drug program . A body at different developmental stages of Schistosoma japonicum Schistosoma japonicum quantitative sensitivity of artesunate infected mice infected 2h, 1d , 3d , 7d, 12d , 14d , 16d , 25d , 35d and 42 days , respectively, after a single intragastric service 500mg/kg artesunate , four weeks after administration anatomical mouse portal vein infusion parasites collected calculated worm reduction rate . Results : 1d , 3d , 7d , 12d , 14d, 16d , 25d, 35d and 42 d treatment group rats worm reduction rate were 16.9% , 18.0% , 71.3% , 50.2% , 36.9% , 31.3% , 45.3% , 58.0% , 26.4% . 1 ~ 42d old mice suggesting that artesunate Schistosoma japonicum are killing role but more obvious killing effects of 7 ~ 35 d of age parasites . Sensitivity to artesunate , Second vitro of different developmental stages of Schistosoma japonicum Schistosoma japonicum cercariae and miracidia exposed to different concentrations of artesunate solution observed after different times of change and survival of its morphology , physical forms . Results : When cercariae exposed to a 20 × 10-3mol / L solution of artesunate , the cercariae head , body instantly transient severe swing , swing speed then began to slow down , head , body stretched straight the first \
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