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Process Study on Compound Paracetamol and Chlorphenamine Maleate Capsules

Author: WangJie
Tutor: ShangZhenHua
School: Hebei University of Science and Technology
Course: Medicinal Chemistry
Keywords: Compound Paracetamol and Chlorphenamine Maleate Capsule Polygonum cospidatum the climbing groundsel draw spray dry adjuvants stability
CLC: TQ461
Type: Master's thesis
Year: 2010
Downloads: 16
Quote: 0
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Abstract


Compound Paracetamol and Chlorphenamine Maleate Capsules were studied in this paper. Through process screening and optimization, the extraction process of Polygonum cospidatum and climbing groundsel was obtained and the production technique and the formulation were founded.First of all, the density, quantity, extraction time, extraction number of times of extraction resolver of Polygonum cospidatum and the climbing groundsel were inspected through the experiments. The best extraction conditions were obtained and the extraction process route and produced the qualified traditional Chinese medicine raw material of Compound Paracetamol and Chlorphenamine Maleate Capsule was formulated.Secondly, under the existing equipment,utilizing glass temperature principle,the process of spray drying working procedure of Polygonum cospidatum and the climbing groundsel was optimized.The quality and yield of the dry powder have been improved greatly, the energy consumption and spray drying time have been reduced effectively,and producing powder rate of dry powder have been improved greatly.Moreover, we made the research to improve the production processes of the compound made of two or more ingredients ammonia Polygonum cospidatum capsule.By changing the means of adjuvants and add method of adjuvants,we enriched the production technology with more rationality and effectiveness, making the products save energy consumption and reduce producing cost on the premise of ensuring the quality of products. All of this laid a foundation for producing on a large scale in the future.Finally, we carried on the stable inspection.Through the acceleration stability test and the content change analysis,we further confirmed the reliability of prescription screening and the craft optimization which were applied in the research of the compound made of Compound Paracetamol and Chlorphenamine Maleate Capsule.

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