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In recent years, the the polymer hydrogels material because of its good hydrophilic properties and excellent biocompatibility in the field of bio-medicine, a lot of attention. Oral controlled release formulations of pharmaceutical dosage forms in recent years, the rapid development of a class of medication, compliance has become the hotspot of research and development. The hydrogel material in the water-swellable crosslinked state is formed a semi-solid, can delay the release of the drug. In this paper, hydroxypropyl methyl cellulose (HPMC) as the raw material to prepare internal hydrogel microsphere, having a three-dimensional network structure of the hydrogel microspheres as drug carriers on the release behavior of the drug theophylline. First, as raw materials with HPMC, divinyl sulfone (DVS), crosslinking agent, cyclohexane as the continuous phase, adding a dispersing agent, and successfully prepared by inverse suspension process having a three-dimensional network structure of the hydrogel microspheres. Amount of catalyst, the HPMC solution concentration, the amount of dispersant and stirring speed performance of the reaction system stability and product particle size, porosity, and further study of the porosity of the hydrogel microspheres of water absorption and water retention impact, and analyzed with a differential scanning calorimeter (DSC), the state of the water in the hydrogel. Second, the preparation of a hydrogel microspheres applied to drug release hydrogel microspheres as a drug carrier for drug loading and release behavior of theophylline. The results showed that the drug loading up more than 9%, while the drug release time up to 15h hydrogel microspheres sustained release theophylline release. Finally, HPMC as raw materials, theophylline Preparation of template molecules molecularly imprinted hydrogel microspheres as a drug carrier release behavior of theophylline, and look at the amount of template molecules, the amount of crosslinking agent and other factors on the water gel drug loading and drug release behavior. The results show that the molecular imprinting technique can significantly improve drug loading and release time of the hydrogel microspheres, drug loading up to 18% more than twice that of non-imprinted hydrogels. Further, by adjusting the amount of the template molecule, the amount of crosslinking agent and other factors, the molecular imprinting the hydrogel microspheres theophylline can be realized a release of theophylline, to achieve the sustained release request. Wherein theophylline / HPMC is 6%, DVS / HPMC for the sample of 20% in 22h approximate zero-order release, the release behavior of theophylline and to the requirements for the controlled release of.
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