Dissertation > Excellent graduate degree dissertation topics show

Study of Surface Modification of Biomedical Microcoil Materials

Author: JiangXiaoSong
Tutor: ChenJunYing
School: Southwest Jiaotong University
Course: Materials Physics and Chemistry
Keywords: TiO2 film unbalanced magnetron sputtering Collagen Type I platelets endothelial cell
CLC: TG174.4
Type: Master's thesis
Year: 2007
Downloads: 47
Quote: 0
Read: Download Dissertation

Abstract


The thrombus formation ability and endothelialization of biomedical microcoil for hemangioma treatment are the basic requirements in clinical intervention application. Surface modification of biomedical microcoil can improve its thrombus formation ability and endothelialization.In this paper, TiO2 biological function films were chosen as a research system for the problem of recent biomedical microcoil. Three kinds of TiO2 films were synthesized by unbalanced magnetron sputtering. The structure, component, and micromorphology of the films were investigated by X-ray diffraction （XRD）, X-ray photoelectron spectroscopy （XPS）, Atomic force microscope （AFM）, and Scan electronic microscope （SEM）. At the same time, the contact angles of the films were measured. The thrombus formation ability of the films was studied by in vitro platelets adhesion test. The results indicated that a certain characteristic TiO2 flim has increasing thrombus formation ability. Furthermore, the biological behavior of cultured human umbilical vein endothelial cells （HUVECs） onto different films was investigated by the in vitro HUVECs cultured experiment. The results showed that the endothelial cells on optimized TiO2 flim surface have good adherence, growth and proliferation.On the basis of our previous study, TiO2 films were synthesized by unbalanced magnetron sputtering. The TiO2 film was then pretreated by NaOH solution for activity.Using bio-chemical modification method,Collagen Type I was further immobilized onto the TiO2 film surface by silane coupling reagent（APTE） to form physical absorption/chemical graft Collagen Type I coat .Scanning electron microscopy （SEM）, X-ray photoelectron spectroscopy （XPS）, Fourier Transform Infrared spectroscopy （FTIR）, Atomic force microscope （AFM） and contact-angle measurement were used to investigate the characteristics of the bio-chemical modificated TiO2 film and the control TiO2 film.The thrombus formation ability of the films was studied by in vitro platelets adhesion test. The results indicated that the bio-chemical modificated TiO2 flim has increased thrombus formation ability. Furthermore, the biological behavior of cultured human umbilical vein endothelial cells （HUVECs） onto different films was investigated by the in vitro HUVECs cultured experiment. The results showed that the endothelial cells on the bio-chemical modificated TiO2 flim surface have good adherence, growth and proliferation.All these results indicated that surface modifications of TiO2 flim and immobilization of collagen type I can improve biological properties of biomedical microcoil .Therefore, these provided a surface biomodification way for improving the biocompatibility of biomedical microcoil to gain good clinical curative effect.

Related Dissertations

  1. Nano- TiO 2 Photocatalytic Preparation and characterization of composite films,TB383.2
  2. Study on Preparation and Property of V2O5 /TiO2 Composite Film Via Microarc Oxidation,TB43
  3. Comperative Experiment on the Toxicity of Particulate Matter from Different Cities,R114
  4. GDF-5 and Rabbit Disc in Vitro Model Induction BMSCs of Rabbit Differentiation to the Nucleus Pulposus Cell,R329
  5. Propranolol for Haemangiomas-insight into VEGF/ERK Signaling Transduction in HUVEC-12 Cells,R965
  6. Effects of 5-Aminolevulinic Acid in the Photodynamic Photorejuvenation Therapy of Intense Pulsed Light,R751
  7. The Polymorphism of Sites 373 and 1688 of PECAM-1 Gene in Mucocutaneous Lymph Node Syndrome in Children,R758.6
  8. pEGFP/Ang-1 Transfected BMSCs Attenuates High Glucose Concentration-induced Choroido-retinal VECs Damage,R774.1
  9. Relaionship among Expression of ESM-1, VEGF-D, Lymphangiogenesis and Lymph Node Metastasis in Human Invasive Lobular Breast Cancer,R737.9
  10. Experiment Study of Wnt/β-catenin Signaling Pathway in the Pathogenesis of Osteoarthritis,R684.3
  11. PECAM-1 Gene Polymorphisms in the Exons 3 and 8 with Coronary Heart Disease in the Han of Western Liaoning,R541.4
  12. Fabrication of Ag~+ Doping Titania Film on 304 Stainless Steel Substrates and Anti-corrosion Properties Research,TG174.4
  13. Effect of Continuous Blood Purification on Prognosis and Endothelial Cell Function in Patients with Severe Sepsis,R459.7
  14. A Study of Inspection Methods of Vascular Endothelial Growth Factor (VEGF) in Peripheral Venous Blood of Patients with Breast Cancer,R737.9
  15. The Relationship between the Expression of Signal Transducers and Acti-vators of Transcription STAT3 and Vascular Endothelial Growth Factor Expression and the Clinical Biological Behavior in Gastric Cancer,R735.2
  16. Clinical Study of Serum Matrix Metalloproteinase-9 and Transforming Growth Factor-β1 Related with Type 2 Diabetic Patients with Nephropathy LI Zhen-zuo. Taishan Medical College, Taian, China 271000,R587.2
  17. The Research of Tat Peptide-Assisting USPIO Crossing the Blood Brain Barrier Model,R-332
  18. The Effect of Drug-Containing Serum of RAS on Cell Viability of Huvec Oxidative Damage Model by H2O2 Induced,R285
  19. The Effect of Drug-Containing Serum of Slr on Cell Viability of Huvec Oxidative Damage Model by H2O2 Induced,R285
  20. Experimental Study on the Influence of Extract of Hawthorn Leaf in Dyslipidemia Rabbits’ Damnification of Vascular Endothelium,R285.5
  21. The Preparation and Properties of TiNi Sharp Memory Alloy for Medical Application,TG139.6

CLC: > Industrial Technology > Metallurgy and Metal Craft > Metallurgy and Heat Treatment > Metal corrosion protection,metal surface treatment > Corrosion control and protection > Metal surface protection technology
© 2012 www.DissertationTopic.Net  Mobile