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Objective: glucose monitoring system (continuous glucose monitoring system, CGMS,) monitoring in patients with type 2 diabetes days glycemic excursion, explore its relationship with HbAlc, C peptide and chronic complications of diabetes. Method: select newly diagnosed type 2 diabetes patients with 24 cases, the application of continuous glucose monitoring system (CGMS) continuous glucose monitoring for 72 ± 6 hours, calculated days at different time points, the level of glycemic excursion periods (GE), and days of average blood glucose levels (24hMBG ); simultaneous determination of a day five times (including fasting, after meals and at bedtime) refers to blood glucose, body mass index (BMI), waist-to-hip ratio (WHR), glycosylated hemoglobin (HbAlc), C peptide, urinary microalbuminuria the protein (UAER) and hyperlipidemia four fundus photography, transcranial Doppler ultrasound (TCD) and ankle-brachial (ABI) measurements to investigate the relationship between GE and chronic complications of diabetes, and to find the impact of days of the time of the level of glycemic excursion segment. Results: 1. The HbAlc AND 24hMBG was a significant positive correlation After breakfast, 3:00 am to 6:00 pm, 1h blood sugar of drift and 22:00,0:00 of blood glucose levels were positively correlated, and 3:00 am to 6:00 pm, dinner The 1h and breakfast after the 3h PPGE is independent impact factors, HbAlc with the average level of glycemic excursion (MAGE) is not relevant. 2. Around the average glycemic excursion (MAGE) with breakfast, hors d'1h GE was a significant positive correlation, and before and after breakfast, hors d'1h GE is independent influencing factors. 3. Fasting C-peptide before breakfast 1h, 2h after breakfast, 3h postprandial 2h, 3h, 1h, 2h after dinner blood glucose drift was negatively correlated with the 2-hour postprandial C-peptide and breakfast 3h, postprandial 2h, 3h, dinner 1h glycemic excursion was negatively correlated with fasting C-peptide and two hours postprandial C-peptide MAGE were not correlated. 4. Diabetic retinal lesions (DR) with breakfast 2h, 22:00 to 24:00 GE nights were positively correlated, and 2 h after breakfast, 22:00 to 24:00 GE were independent risk factors for DR, DR and HbAlc , MAGE were not correlated. 5. Diabetic nephropathy (DN), ABI, TCD, lipids (TG, TC, LDL, HDL) and HbAlc and day different periods of GE are not related, and BMI are independent risk factors of DN; the 22:00 blood glucose value is ABI an independent risk factor. Conclusion: HbAlc can accurately reflect the average blood sugar levels throughout the day, but does not reflect the average glycemic excursion day, the glycemic excursion may contribute to the occurrence of diabetic retinopathy, the islet dysfunction may be one of the reasons glycemic excursion.
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