Dissertation > Excellent graduate degree dissertation topics show

Effect of Gestational Diabetes Mellitus on Thyroid Function in Neonates

Author: YinWei
Tutor: SunZhengZuo
School: Shandong University
Course: Clinical
Keywords: the gestational diabetes Newborn babies Thyroid function Bloodsugar Insulin c-peptide
CLC: R722.1
Type: Master's thesis
Year: 2012
Downloads: 114
Quote: 0
Read: Download Dissertation

Abstract


Background and objective:Gestational diabetes (gestational diabetes mellitus, GDM), refers to the process of pregnancy first found diabetes, regardless of whether the situation after the birth of a sustained or whether need insulin or single diet therapy. Pregnancy GDM easy appear too much amniotic fluid, such as high blood pressure, childbirth damage and cesarean section rate was also increased significantly. Gestational diabetes mother of childbirth newborn can appear large children, respiratory distress syndrome, low blood sugar, maternal injuries, congenital malformation, hyperbilirubinemia occurs and so on a series of complications, adolescent and adult for high blood pressure, obesity, diabetes, as well as the risk of disease were higher. Now consider the pathogenesis of GDM to insulin resistance, hormonal imbalance, gene, cell factor closely related. Because the nerve, endocrine, immune three system between, through the same peptide hormone and common receptor influence each other, forming a complete adjusting loop, pregnancy mother’s high blood glucose, and high insulin hematic disease environment of the organs of fetal growth, endocrine, thyroid function may have an impact. However, about the gestational diabetes mother newborn whether thyroid function disorder, and all the indexes of thyroid function abnormal degree, the domestic and foreign relevant reports are relatively few. This study testing gestational diabetes mother of umbilical cord blood of the babies childbirth, T3、FT3、T4、FT4、TSH, insulin, c-peptide, the change of blood sugar, and neonatal weight, height, head circumference and foraging reflection, sucking reflex, and hold reflection, hug reflection primitive reflex, etc, and normal controls, this paper discusses the gestational diabetes to the newborn thyroid function, and the influence of the thyroid function and the index of blood sugar, c-peptide, insulin related, to reduce GDM mother during the complications of the newborn, improve the development of nervous system, prevent treat various diseases, provides the basis.Methods:1. The research object choice and group: Selection of linyi maternity hospital in maternity and child care centers and diagnosis of gestational diabetes during the women of the term newborns40cases as research group, its parent no thyroid disease, taking hormone drugs, pregnancy and hypertension syndrome, rheumatism, metabolism, immunity, blood system and other may affect the function of the thyroid disease; According to the blood sugar control during pregnancy, divided into blood sugar control good group of21, poor control group of19. According to the birth weight into large children group in18cases, normal weight group of22patients. In the same period the health of the selection, pregnancy delivery term40patients healthy newborn babies as control group. Each gender, age were no statistically significant differences were found.2. T3、FT3、T4、FT4、TSH detection:the electrochemical luminescence3. Blood sugar test:glucose oxidase method4. Insulin detection:ria analysis method C-peptide test:ria analysis methodThe results:1. The observation group T3、FT3、T4、FT4、blood sugar lower than those of the control group (P<0.05); TSH, c-peptide, insulin was significantly higher than the control group (P<0.01).2. Poor control of blood sugar group and control group good comparison:poor control of blood sugar group, T3、FT3、T4、FT4blood sugar are lower than those of control group is good, TSH, c-peptide, insulin higher than control group good (P<0.05).3. Great son group group compared with normal weight, T3、FT3、T4、FT4reduce blood sugar have a statistics difference (P<0.01), TSH, c-peptide, insulin increased significantly.(P<0.05);4. The observation group and control group hypoglycemia happen is:the observation group has six case of hypoglycemia, only one case occurred low blood sugar control. The incidence of hypoglycemia between the two groups was statistically significant difference (P<0.05)5. The observation group and control group neonatal development level is:a control group, GDM neonatal weight is larger, the small head circumference. The original reflection more difficult to draw out, or reflects not completely. The difference between both groups was statistically significant (P<0.01).6. The observation group thyroid function and blood sugar, c-peptide, insulin correlation analysis: The observation group of thyroid function index and blood sugar, c-peptide, insulin for Pearson correlation analysis shows that T3、FT3、T4、FT4and blood sugar is moderate are related (P<0.01), FT3、T4、FT4and c-peptide, insulin is negatively related to the moderate (P<0.01), T3and insulin is negatively related (P<0.01).Conclusion.1. Pregnancy high blood glucose, and high insulin hematic disease environment on fetal thyroid function impact. T3、FT3、T4、FT4、TSH abnormal and glucose, insulin, c-peptide abnormal relevant. GDM newborn weight and blood sugar value different different neonatal thyroid function, there are differences, low thyroid disease, the occurrence of birth weight and blood sugar closely related, or large children born hypoglycemia, endocrine system damage, synthetic thyroid hormone enzyme system by inhibiting, can make the thyroid function is low.2. GDM neonatal head circumference slants small, the original reflection abate, the influence of the newborn brain development. Pregnancy blood sugar control, reduce large children, can improve the level of the newborn thyroxine GDM, reduce the risk of falling behind the development of nervous system.

Related Dissertations

  1. Study on Relationship between Endothelin-1, Insulin Resistance and Acute Ischemic Cerebrovascular Disease,R743.3
  2. Broiler Responses to Reduced-protein Diets Suppleme Nted with Synthetic Amino Acids and Small Peptides,S831.5
  3. Study on Taste Characteristic of Taste Peptide Enzymatic Production from Oyster Base on A Neural Network Method,TS254.4
  4. Synthesis and Identification of P22/P221 Polypeptides of IBDV Ligand Epitope and Screening CEF Library,S852.65
  5. Study on Processing of Germinated Soybean Accumulating Peptides and Its Soybean Milk,TS214.2
  6. Determination of Soil Enzyme Activity and Extraction, Purification and MS Identification of Soil Microbial Total Protein,S154
  7. Continuous Ultrafiltration Treatment Congestive Heart Failuer for c-Reactive protein and N. Terminal Pro. Brain-Nariureic Peptide,R541.61
  8. Identification of Genes Related to Virulence of Fusarium Graminearum and Biopaning of DON Toxin Specific Affinity Peptides,S432.4
  9. Efficacy and Safety of Biphasic Insulin Aspart 30 Once-daily Treatment in Patients with Type 2 Diabetes,R587.1
  10. Expression and Significance of HIF-1α on the Insulin Resistance during the Injury of Reperfusion of Ischemic Myocardium in Dog Undergoing Cardiopulmonary Bypass,R654.1
  11. Plasma Galectin-3 Levels and Its Prognostic Value in Patients with Heart Failure,R541.6
  12. Serum Levels of Insulin Like Growth Factor-1 and Cardiovascular Remodeling in Patients with Hypertension,R544.1
  13. Effect of Gastric Bypass on the Blood Glucose Level in Type 2 Diabetes Rat Model,R587.1
  14. Study Finds Best Use of Insulin as Diabetes Progresses and Impact Factors of Insulin Treatment of Diabetic Patients,R587.1
  15. The Comparative Analysis of the Effect to Diabetes of Insulin Pump and Hypoglycemic Agents,R587.1
  16. Analysis of the Insulin Dose and Impact Factors of Insulin Pump Treatment of Type 2 Diabetic Patients,R587.1
  17. The Influences of Blood Glucose Levels on the Function of Neutrophil-moncyte Cell Line HL-60 Cells,R587.1
  18. The Clinical Research on Changes of the Level of C-peptide、Insulin and Cortisol in Premature Infants Hypoglycemia,R722.6
  19. The Protective Effects of Glucagon-like Peptide -2 on Intestinal Barrier Function of Doxorubicin Chemotherapy in Rats,R730.5
  20. Effects of Osteogenic Growth Peptide and Insulin-like Growth Factor-I on Biological Function in Cultured Human Periodontal Ligament Cell,R781.4
  21. Shamisen Medicinal and Edible Herbs on glucose and lipid metabolism in the metabolic syndrome and antioxidant effects,R285.5

CLC: > Medicine, health > Pediatrics > Newborns, premature children disease > Neonatal disease
© 2012 www.DissertationTopic.Net  Mobile