Dissertation > Excellent graduate degree dissertation topics show

Significance of Chemokine Receptor CXCR3 Expression in Breast Cancer

Author: LiLei
Tutor: LuChaoHui；ChenJie
School: Beijing Union Medical College
Course: Pathology and Pathophysiology
Keywords: Breast tumor Receptor , CXCR3 Tumor metastasis
CLC: R737.9
Type: Master's thesis
Year: 2010
Downloads: 61
Quote: 0
Read: Download Dissertation

Abstract


Objective To study the chemotactic factor receptor CXCR3 expression in breast cancer , and to analyze the relationship between invasive breast cancer clinicopathological parameters . Methods RT-PCR and real-time quantitative PCR (Real-Time PCR) detection CXCR3 mRNA expression in 18 cases of invasive breast cancer tissue carcinoma and adjacent normal tissue ; using immunohistochemical methods to detect CXCR3 in 80 cases of invasive breast cancer expression in 20 cases of breast fibroadenoma and 15 cases of normal breast tissue . Results ( 1 ) RT - PCR and real-time fluorescence quantitative PCR results showed that CXCR3 mRNA expression levels in breast cancer tissue was significantly higher than in adjacent normal tissues ( P lt; 0.05 ) . (2) The results of immunohistochemistry of CXCR3 expression in breast cancer tissue was significantly higher than its expression in breast fibroadenoma and normal breast tissue (P lt; 0.05); lymph node metastasis in breast cancer tissue group CXCR3 expression was significantly higher than that of CXCR3 expression levels of breast cancer patients with lymph node metastasis group ( P lt; 0.05 ) ; involving the number of lymph node metastasis , tumor size and pTNM stage was a significant positive correlation ( P lt; 0.05 ) . Conclusion chemotactic factor receptor CXCR3 is an important molecules involved in breast cancer progression , its expression of a number of clinicopathological parameters , especially lymph node metastasis , suggesting that its as a predictor of breast cancer lymph node metastasis and prognosis of immunopathology indicators.

Related Dissertations

  1. The Expression of Brms1、 KIss1 and CD82 in Gastric Cancer and Its Clinical Significance,R735.2
  2. Study on Segmentation of Breast Tumor in Ultrasonogram,TP391.41
  3. Survivin, Bcl-2, PCNA in Breast Cancer’s Expression and Significance,R737.9
  4. Construction and Expression of Fusion Gene （RGD）3 - DAB391 Prokaryotic Expression Vector and Study of Its Tumor Depression Effect in Vitro,R737.9
  5. The Clinical Research about the Ginkgo Leaf Injection Cure of the Tumor High Congealed State,R730.5
  6. Evaluation Forthe Efficacy of Neoadjuvent Chemotherapy in the Treatment of Breast Cancer with Conventional Ultrasound and Contrast-enhanced Ultrasound,R737.9
  7. Cloning of Full Length Heparanase Gene and Expression of Functional Heparanase in Mammalian Cells,R730.2
  8. Investigate the Clinical Application Value of Breast Blood Oxygen Functional Image Technology,R737.9
  9. Over-expressions of Macrophage Migration Inhibitor Factor and Cyclin D1 Correlates with Clinical Pathologic Characteristics of Pancreatic Carcinoma and It Significance,R735.9
  10. Radiosensitizing Effects of Arsenic Trioxide on Human Breast Cancer MCF-7 Cell Line Exposed to 89 Strontium Chloride,R737.9
  11. Evaluation of the Ultrasound and Mammography for Breast Cancer Diagnosis of Stratification,R737.9
  12. Small Doses of Megestrol Acetate in Combination with Tamoxifen for Breast Cancer Research on the Effect of Endocrine Therapy,R737.9
  13. Lymphoscintigraphy Combine Staining in Diagnose of Internal Mammary Sentinel Lymph Nodes of Breast Cancer: A Pilot Clinical Study,R737.9
  14. α1, 3 fucosyl transferase Ⅳ (Fut4) upregulated increased metastatic potential of squamous cell scc12,R730.2
  15. The Study on the Relationship between Apoptosis-related Gene Bcl-2 and Clinical Biological Behavior of the Breast Cancer,R737.9
  16. Study of Postoperation Radiotherapy in Early Breast Cancer Patients with 1～3 Axillary Lymph Nodes Metastasis,R737.9
  17. Expressions of PTTG, OPN and bFGF Protein in Cervical Squamous Cell Carcinoma and Their Clinical Significance,R737.33
  18. ATF3 activation and its target gene expression and invasion and metastasis of hepatocellular carcinoma correlation,R735.7
  19. Investigation on the Influence of the Different Incision Selections on the Breast Surface Beauty in the Excision Surgeries of Mammary Benign Tumors,R655.8
  20. Monocyte Chemoattractant Protein -1 Involved in the Activation and Regulation of Osteoclasts in Bone Tumors,R738

CLC: > Medicine, health > Oncology > Genitourinary tumors > Breast tumor
© 2012 www.DissertationTopic.Net  Mobile