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Recombinant Human Endostatin Combined with NP Chemotherapy in Treatment of Human Breast Cancer Xenograft in Nude Mice

Author: ZhangZuo
Tutor: WeiQiChun
School: Zhejiang University
Course: Oncology
Keywords: Breast Cancer Recombinant human endostatin Chemotherapy VEGF HIF-lα P53
CLC: R737.9
Type: Master's thesis
Year: 2010
Downloads: 19
Quote: 0
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Abstract


Objective: To investigate recombinant human endostatin in combination with chemotherapy nude mouse model of human breast cancer treatment effects were observed on xenograft tumor angiogenesis and tumor growth inhibition . : Bearing nude mice 40 were randomly divided into 4 groups , respectively, for the chemotherapy group , endostatin group , the combined treatment group and the control group were given chemotherapy, endostatin , endostatin chemotherapy and saline , comparing each inhibited tumor growth , tumor growth curve . Immunohistochemistry was used to detect tumor MVD , VEGF , HIF -1α and P53 expression . Results: The combined group inhibition rate was 64.63% and the chemotherapy group inhibition rate was 35.47% . Combined treatment group and the other three groups , MVD and VEGF was significantly reduced, and the difference was statistically significant ( p lt; 0.05 ) . The expression of HIF-1α combined treatment group was significantly lower than the control group , a statistically significant difference ( p lt; 0.05 ) . Reduced groups P53 expression compared with control group , the difference was statistically significant ( p lt; 0.05 ) . Combination group compared with chemotherapy P53 group , a statistically significant difference ( p lt; 0.05 ) . Conclusion: The experiments show that recombinant human endostatin combined with chemotherapy can effectively control nude mouse mammary tumor growth and decreased tumor microvessel density , its mechanism may be lowered expression of VEGF and HIF-1a , provided the experimental basis for our clinical drug . Endostatin the P53 mechanism needs deeper research .

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CLC: > Medicine, health > Oncology > Genitourinary tumors > Breast tumor
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