|
Objective: various complications of diabetes (Diabetes mellitus, DM), especially macrovascular disease has become one of the main reasons of morbidity and mortality in patients with DM, its pathogenesis is not yet fully understood. In recent years; growing evidence that inflammation plays an important role in the pathogenesis of type 2 diabetes (Type2 Diabetes Melltius, T2DM) and T2DM is a natural immune disease and low-grade inflammation, peripheral blood leukocytes (Leukocyte, WBC) inflammatory cytokines interleukin -6 (Interleukin-6, IL-6) as a clinical chronic inflammation markers in its role in the pathogenesis of concern. The purpose of this study is to: 1. Observation of IL-6, WBC, course of disease, body mass index (Body mass index, BMI), systolic blood pressure (Systolic blood pressure, SBP), diastolic blood pressure (Diastolic blood pressure, DBP), glycosylated hemoglobin (Glycosylated haemoglobin Alc, GHbAlc), total cholesterol (Total cholesterol, TC), triglycerides (Triglyceride, TG), fasting blood glucose (Fasting plasma glucose, FPG), 2-hour postprandial blood glucose (2 Hours postprandial plasma glucose P2PG,) a series of indicators, fasting insulin (Fasting plasma insulin, FINS) in T2DM with carotid artery disease (Vascular disease of the carotid artery, VDCA) when the concentration changes. 2. Investigate IL-6, the WBC merged in T2DM VDCA with the relationship between the various factors, the role to the occurrence of macrovascular complications of T2DM by development to achieve early diagnosis, early prevention purposes. Methods: A controlled study group. Study: Select T2DM patients Shandong Province Qianfoshan hospital in October 2005 October 2006 60 people, including 32 male and 28 females, age (51.82 ± 8.62) years. All enrolled cases of diabetes diabetes diagnosis based on the 1999 WHO classification criteria, duration of the meet from 1 month to 14 years. According to the presence or absence of the VDCA the T2DM divided into two groups, each group 30 cases observed object. The healthy control group of 31 cases. Measuring indicators: All subjects caught measured BMI, SBP, DBP, FPG, HbA1c, TC, TG, P2PG FINS range of indicators. ELISA (Enzyme linked immunosorbent assay, ELISA) serum IL-6 levels; automated blood cell analyzer complete peripheral WBC count and classification. Carotid Determination: Color Doppler Ultrasound carotid intima-media thickness (Intima media thickness, IMT), hardened, plaque and stenosis formation. Results: 1.T2DM accompanied or not accompanied the VDCA by serum IL-6, and the peripheral WBC level significantly higher than the control group (P lt; 0.01). 2.T2DM accompanied VDCA serum IL-6 level of peripheral WBC less associated with the VDCA those levels were significantly elevated and the difference was statistically significant (P lt; 0.01). 3.DM serum IL-6 levels and peripheral WBC between was a positive correlation (r = 0.797, P lt; 0.05). The Conclusion: 1.T2DM peripheral blood of patients with WBC and serum IL-6 levels than normal, suggesting that both play an important role in the occurrence and development of T2DM. 2.T2DM accompanied VDCA peripheral WBC less serum IL-6 levels associated with the VDCA significantly increased, suggesting an important role to play both in T2DM macrovascular complications. . Was a positive correlation between peripheral WBC and serum IL-6 levels, suggesting that both T2DM and its vascular complications, affect each other in the development of joint action, detection of both levels and changes for early clinical diagnosis and treatment VDCA provides a theoretical basis.
|