|
Purpose in accordance with the herders drinking habits chronic brick tea aluminum and fluorine poisoning and low-fluoride the low aluminum brick tea model, aluminum fluoride brick tea observation and analysis, learning memory, nervous system, blood system, skeletal system and the impact on the body weight of rats aluminum fluoride content, organization explore pathophysiological mechanisms brick tea aluminum and fluorine poisoning. Radical brick tea-type aluminum fluoride poisoning provide a theoretical basis. Weaning 4 weeks 24 male Wistar rats, female, 36, were randomly divided into six groups. Blank control group (drink tap water), aluminum single group (drinking aluminum-containing 159mg / L), a single fluoro group (water fluorine-containing 100mg / L), the aluminum fluoride joint group (drinking aluminum-containing 159mg / L, a fluorine-containing 100 mg / L) , brick group (drinking brick tea water), low fluoride tea group (low fluoride drink tea water). Groups begin with the preparation of drinks for the only source of drinking water, free diet, every three months in the experimental measured body weight of rats; experiment last two months of learning and memory evaluation; were killed after the end of the experiment (one year), to measure the brain tissue somatostatin content; observe the microstructure of the brain, liver, spleen, kidney; and measured blood and serum, kidney, liver, bones, teeth, brain fluorine, aluminum content. Experimental data obtained as mean ± standard deviation (X ± S), SPSS 13.0 software was used for statistical analysis and processing, test level to take alpha = 0.05. Aluminum can increase the body weight of rats (p lt; 0.05); aluminum and fluorine than single aluminum slow but long-lasting and severe (p lt; 0.05); low fluoride tea can make an age weight loss in rats (p lt; 0.05). Aluminum-induced learning and memory dysfunction (p lt; 0.05); aluminum and fluorine serious than the single aluminum (p lt; 0.01); the brick tea also cause learning and memory dysfunction (p lt; 0.05). Fluorine, aluminum caused by the decline in number of rat hippocampal SS (p lt; 0.05); aluminum and fluorine serious than the single aluminum (p lt; 0.01); brick tea the single fluorine serious (p lt; 0.01). High concentrations of fluoride can increase the MCV in rats, PLT (p lt; 0.05); the low fluorine tea can reduce the rat HCT, MCV, MCHC (P lt; 0.05) The high concentration of aluminum can promote fluorine absorption and accumulation in serum, bone, teeth, brain, liver; high concentrations of aluminum accumulation in serum, bone, teeth, brain (p lt; 0.05), high concentrations of fluorine can be suppressed aluminum absorption. Brick tea cause bone, the teeth, liver fluorine content increased (p lt; 0.05), and teeth, liver aluminum content increased (p lt; 0.05); low fluoride tea cause kidney, liver aluminum content increased (p lt; 0.05) Aluminum and fluorine and aluminum single group of rat brain cerebral edema; the aluminum fluoride joint and single fluorine renal proteinuria; the aluminum fluoride joint and brick tea hepatic necrosis small area of ??the dot. Conclusion 1, successfully copied the rat model of brick tea aluminum and fluorine poisoning. 2, the fluorine element against the target organ is the bone and teeth, and can cause damage. Aluminum elements for the target organ is the bone, teeth and brain, can cause stunted growth and learning and memory dysfunction. 3, when the aluminum fluoride exists at the same time, the high concentration of aluminum can promote fluorine absorption, high concentrations of fluorine can inhibit the absorption of aluminum. 4, the choice of a low fluoride tea instead of ordinary brick tea, can not affect the the brick tea taste and color under the premise, the prevention of brick tea aluminum and fluorine poisoning fat cow
|