Dissertation > Excellent graduate degree dissertation topics show

Primary Study on the Inhibition of Formation of Intracranial Aneurysm by an Inhibitor of SRK Kinase-PP2

Author: ZhangXianHua
Tutor: LiMeiHua
School:
Course: Surgery
Keywords: Intracranial aneurysm Sprague-Dawley Animal model PP2 PP3 Elastin Van Gieson Stain HE Staining
CLC: R739.4
Type: Master's thesis
Year: 2013
Downloads: 3
Quote: 0
Read: Download Dissertation

Abstract


Objective:The etiology of the intracranial aneurysm is unclear. In our previous study it wasfound that SRC kinase may play a certain role to some extent in the formation of theintracranial aneurysm by regulating the phosphorylation of vascular endothelialcadherin (VE-cadherin)and its relevant signal pathway. This paper is designed tostudy the inhibition of the formation of intracranial aneurysm by PP2, an inhibitor ofSRC kinase.Methods:160male SD rats were divided into two groups randomly, of which140ratswere used to create experimental intracranial aneurysm animal model, and theremaining20rats as the nomal control.140male SD rats were subdivided into7sub-groups,which included40-μg and20-μg PP2treatment sub-groups at early stage,40-μg and20-μg PP2treatment sub-groups at late stage,40-μg and20-μg PP3treatment sub-groups at early stage,40-μg and20-μg PP3treatment sub-groups at latestage and the positive control group.The vessels at the bifurcation of right anteriorcerebral artery-olfactory artery (ACA-OA) were sampled to observe the formation ofthe intracranial aneurysms.Results:The formation rate of intracranial aneurysm was20%(4/20)in both sub-groupsof40-μg and20-μg PP2treatment at early stage,40%(8/20)and45%(9/20)insub-groups of40-μg and20-μg PP2treatment at late stage respectively,50%(10/20)and55%(11/20) in sub-groups of PP3treatment at early and late stagerespectively,the fomation rate of aneurysm in the positive control group was55%. Noaneurysm was found in the nomal control group.Compared with the positive control subgroup, the formation rate of intracranialaneurysm in both sub-groups of40-μg and20-μg PP2treatment at early stage wassignificantly decreased (p<0.05), but there was no difference between othersubgroups (p>0.05). Conclusion:PP2,an inhibitor of SRC kinase can obviously inhibit the formation of ratexperimental intracranial aneurysm when used at early stage after the induction ofexperiment aneurysm; however, the inhibition could not found when it was used atthe late stage after the induction of experiment aneurysm. Nevertheless,our resultsfirstly confirmed the inhibition of the formation of intracranial aneurysms in vivo bya SRC kinase inhibitor.

Related Dissertations

  1. Study on the Digestive Tube During the Embryonic Stage of Gushi Chicken,S831
  2. Expression Change of Signaling Molecule Related Wnt Signal Pathway in Mouse Cleft Palate Induced by Retinoic Acid During Perinatal Stage,R782.21
  3. Experiment on Repeated Bone Harvest Chamber in Vivo,R329
  4. The Effect of Hepatic Denervation on Liver Regeneration after Partially Hepatectomy in Rats,R363
  5. Dry Eye Patients Dalian Ophthalmology Out Patient Department Survey,R777
  6. Kainic acid induced epilepsy rat neurons plasticity of dendritic spines,R742.1
  7. Domestic isoflurane inhalation anesthesia effect depends on learning and memory in adult rats related research,R965
  8. Significance of Intraoperative Indocyanine Green Fluorescence Videoagiography during Neurosurgical Procedure,R651.12
  9. Establishment of Nude Mousemodels of MG63 and MG63/ADR Osteosarcoma Cell Lines and the Significance of Expression of VEGF and NF-κB1,R738.1
  10. The Preparation and Application of Anti-staining Agent on Denim Cellulose Washing,TS195.2
  11. Expression of Matrix Metalloproteinase in Rabbit Dry Eye Model,R-332
  12. Feature Analysis of Binding of Anti-CD28 Antibody with Antigen and Studying of Antibody-mediated Effect,R392
  13. The Expression and the Clinical Significance of Integrin αvβ3/αvβ5 in the Prostate Cancer Tissues,R737.25
  14. Expression of Transcriptional Corepressor C-terminal Binding Protein1 (CtBP1) and p16 in Esophageal Cancer,R735.1
  15. Craniofacial Abnormalities in Zebrafish Induced by Clomiphene Sodium Citrate,R114
  16. The Experimental Study about the Effects of α-tocopherol on the Expression of Nogo-A and NgR Proteins in Rats Brain after Tranumatic Brain Injury,R965
  17. The Significance of Cytological Examination of Free Cancer Cell and Expression of CK20 mRNA in the Peritoneal Cavity Washes of Laparoscopic Colorectal Resction Patients,R735.3
  18. The Effect of Hyperbaric Oxygen (HBO) on the Growth of Rat Intracranial Glioma,R739.4
  19. The Clinical Application Value of Sperm Protein AKAP4、GAPDHS、SPANX and A23187-induced Acrosome Reaction Rate in Artificial Insemination,R698.2
  20. Alveolar Echinococcosis of Encephalopathy in Rabbit Model,R-332
  21. Fractal-based non- uniform flow of soil Experimental research and numerical simulation,S152

CLC: > Medicine, health > Oncology > Nervous system tumors
© 2012 www.DissertationTopic.Net  Mobile