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Experimental Study on Protective Effect of Pretreatment with Ulinastatin Combined with Hypertonic Saline on Liver Ischemic Reperfusion Injury in Rats

Author: ZuoJunFeng
Tutor: WangJiaXiang
School: Zhengzhou University
Course: Surgery
Keywords: Liver Ischemia-reperfusion injury Ulinastatin Hypertonic saline Pharmacological preconditioning
CLC: R575
Type: Master's thesis
Year: 2009
Downloads: 2
Quote: 0
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Abstract


Objective To investigate the ulinastatin combined with hypertonic saline pretreatment on rat liver protection effect and mechanism of ischemia-reperfusion injury . Provide theoretical guidance and technical support for its prevention in clinical applications hepatic ischemia-reperfusion injury . 60 method clean healthy male SD rats , weighing about 230g , were randomly divided into five groups , n = 12 , respectively, for the sham control group (A ) , ischemia-reperfusion group (B ) , ulinastatin Ding pretreatment group (C ) , the hypertonic saline pretreatment group (D ) and ulinastatin combined with hypertonic saline preconditioning group (E group) . Pringle Law were established rat hepatic ischemia-reperfusion model , the observed liver ischemia 30min began blood flow reperfusion 6h serum alanine aminotransferase (ALT), aspartate aminotransferase ( AST ) , lactate dehydrogenase (LDH) and tumor necrosis factor -α (TNF-α) , the content , and comparing each group to simultaneously cut the observed pathological changes of the liver tissue . B, C, D and E in serum ALT, AST, LDH and TNF -α were significantly higher than in group A ( P lt; 0.05 ) ; C , D and E group was significantly lower than that of B group ( P lt ; 0.05 ) ; C and D groups was significantly higher than that in group E ( P lt; 0.05 ) ; C group and D group asked the difference was not statistically significance ( P gt ; 0.05) . The liver histopathological damage the heaviest group B , C , D group , followed by A group lightest group E lighter than C, D groups . Conclusion ulinastatin , hypertonic saline pretreatment on rat liver ischemia-reperfusion injury have protective effects , drug associated with better .

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CLC: > Medicine, health > Internal Medicine > Digestive and abdominal diseases > Liver and gall bladder disease
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