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The Study on mtDNA Polymorphism of Chaoshan Population and the Genetic Relationship between Chaoshan Population and Other Populations

Author: FengGuoYing
Tutor: HuShengPing
School: Shantou University
Course: Forensic
Keywords: Mitochondrial DNA Polymorphism Kinship Chaoshan crowd
CLC: R394
Type: Master's thesis
Year: 2009
Downloads: 26
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Abstract

Background: maternally inherited mitochondrial DNA (mitochondrial DNA, mtDNA), lack of recombination, mutation rate and genetic characteristics, and therefore easy to form population-specific genetic markers, is the study of human evolution, population migration history of a useful genetic marker. Because mitochondrial DNA to comply with the strict maternal inheritance, avoid mestizo impact can faithfully reproduce the maternal evolutionary history of the population, and thus through the analysis of mitochondrial differences. The Chaoshan bit too far to the southeast corner of our country, the easternmost Guangdong Province and Fujian Province, adjacent to its geographical level city of Shantou, Chaozhou, Jieyang three. Corresponding ChaoShanRen means living in the region and Han Chinese population own unique dialect and habits. According to historical records, in 214 BC, the the Chaoshan region's main ancestors is Minyue family of Qin and Han migrated to the south, with the descendants of Han nationality and integration with local Aboriginal the Chaoshan then be gradually assimilated to Han. Task Force early genetic marker HLA (Human leucocyte antigen), and autosomal STR (Short tandem repeat) the Chaoshan population anthropological origins studies at the gene level. The findings of the two genetic markers show the Chaoshan Han and southern Han clustering with Minnan Han phylogenetic relationship, and distant with northern Han affinity relationship. STR results of the study also shows the the dominant Han ingredients in the Chaoshan population genetic library, and the less the composition of the indigenous people of the South. Objective: from the point of view of the maternally inherited genetic relationship between the study the Chaoshan populations and other populations, to further explore the the Chaoshan population maternal gene pool genetic component. Method: a the Chaoshan Han population of 120 unrelated individuals hypervariable region (hypervariable segment 1 and hypervariable segment 2, HVS-1 and HVS-2) lack of sequence analysis and CO II / the reversement of tRNALys section 9bp detection, calculation of various haplogroups frequency. First hypervariable region of mitochondrial DNA sequence further collect the rest of the population and the crowd haplogroup frequency data for comparison. Cluster analysis, principal component analysis to study the genetic relationship between the population; the fusion analysis northern Han and southern aboriginal population the size of the contribution rate of maternal gene pool of Chaoshan crowd. Results: The the Chaoshan population haplotype diversity (h) in Zone 1 and Zone 2 were 0.992 and 0.942, nucleotide diversity (π) in Zone 1 and Zone 2 were 0.02153 and 0.01049,9 bp deletion frequency 18.33 %. Chaoshan population, the indigenous peoples of the South haplogroups slightly higher than the proportion of northern Han haplogroups. Cluster analysis and principal component analysis results show Chaoshan population and other southern Chinese Han population clustering. Ingredients of the Southern Aboriginal and northern Han basically half and half the Chaoshan population matriarchal gene pool. In addition, cluster analysis and principal component analysis results show that the apparent north and south boundaries of the Chinese population. Conclusions: The mitochondrial DNA hypervariable region in Chaoshan Han population has a high degree of polymorphism; the Chaoshan population has the genetic characteristics of the southern Chinese Han population; the Chaoshan population matriarchal genetic component originated in northern Han and southern aboriginal; between the north and south China crowd genetic differences.

The Study on mtDNA Polymorphism of Chaoshan Population and the Genetic Relationship between Chaoshan Population and Other Populations

Abstract

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