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The Expression and Biological Significance of Nuclear Factor-kappa B (NF-κB) in Hepaticullar Cancinome

Author: LiangShuai
Tutor: WangZhiMing
School: Central South University
Course: Surgery
Keywords: Nuclear factor-kappa B Hepaticullar cancinome
CLC: R735.7
Type: Master's thesis
Year: 2007
Downloads: 110
Quote: 1
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Abstract


Objective: To investigate the gene expression of nuclear factor-kappa B (NF-kB) and its biological significance in liver cancer tissue.Methods: The samples from cancer tissue and corresponding cancer ambient tissues were collected in thirty-two patients with primary liver cancer. The mRNA and protein levels of NF-kB were determined by reverse-transcription PCR and western bolt, respectively. Immunochemistry was employed to determine the localization of NF-kB protein in liver tissues.Results: As shown by RT-PCR and western blot, both mRNA and protein expressions of NF-kB in liver cancer tissues were significantly higher than those in corresponding cancer ambient tissues (P < 0.05). In liver cancer tissues, NF-kB was showed to express in both cellular nucleus and cytosol, whereas its expression was only detected in cellular cytosol of cancer ambient tissues. The difference of the intracellular localization of NF-kB between liver cancer and cancer ambient tissues implies that NF-kB is activated in liver cancer tissue.Conclusion: NF-kB gene is significantly overexpress and activated in liver cancer tissue, which may consequently modulate transcription of some related downstream-gene and promotes the initiation and development of liver cancer.

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CLC: > Medicine, health > Oncology > Gastrointestinal Cancer > Liver tumors
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