Dissertation > Excellent graduate degree dissertation topics show

Effects of ATRA on Intimal Proliferation on the Path Way of MAPK、PKCα and C-fos in Injured Carotid Artery in Rabbits

Author: WangZuoZuo
Tutor: DongGuoXiong
School: Qingdao University
Course: Internal Medicine
Keywords: retinoic acid vascular smooth muscle proliferation mitogen activated protein kinase oncogene
CLC: R543.4
Type: Master's thesis
Year: 2007
Downloads: 66
Quote: 0
Read: Download Dissertation

Abstract


Objective To investigate the influence of all-trans retinoic acid (ATRA) on thesignal conduction mechanisms of transformation、immigration and multiplication ofvascular smooth muscle cell in rabbit carotid atheroselerosis.Methods Rabbits were randomly divided into three groups: normal group(n=12), control group (n=12) surgical group (n=12) and ATRA treated group(n=12). The other three groups were fed on high-cholesterol diet and control groupwas made into carotid atherosclerosis model by airing after two weeks. The ATRAtreated group was fed on all-trans retinoic acid. On the 14th day and 28th day, thetarget vessels were taken out, PKCα、MAPK and C-fos were observed byimmtmostaining. The carotid arteries were harvested weeks after the operation.Results Proliferation degree and expression level of PKCα、MAPK and C-fosof endomembrane of treated group are respectively lower (P＜0.05) and higher (P＜0.05) than operated group, which are observed morphologically.Conclusion The results indicate that ATRA treatment can inhibit athero-sclerosis progression by inhibiting the proliferation of vascular smooth muscle cells.The mechanism may relates to inhibition of the expression of PKCα、MAFK and C-fosin vascular smooth muscle cells.

Related Dissertations

  1. Expression of Prolyl Isomerase Pin1 in Osteosarcoma and the Effect of Regulation on Cell Cycle,R738.1
  2. Cloth and β- elemene combined administration of anti-tumor effect and mechanism of celecoxib,R96
  3. Synthesis and Quality Control Research of ATPR,TQ463
  4. Effect of Cysteamine on the Rate of Early Successful Weaning and Immunity of Calves,S823.5
  5. In Vitro Culture and Identification of Vascular Smooth Muscle Cells from Rat Intra- and Extracranial Arteries,R743.3
  6. The Experimental Study of Semiconductor Laser Radiation and 5-FU Sustained Release Repressed Oral Malignant Tumor Cell,R739.8
  7. Study on the Cell Cycle of Liver Cells during Rat Liver Regeneration,Q253
  8. Effects of Receptor Activity Modifying Protein-1 Transplantation of Mesenchymal Stem Cells on Postangioplasty Restenosis and Cardiac Function after Myocardial Infarction in Rabbits,R542.22
  9. Effects of Osteogenic Growth Peptide and Insulin-like Growth Factor-I on Biological Function in Cultured Human Periodontal Ligament Cell,R781.4
  10. Corniculatus LjCYC2 gene on the genetic transformation of ornamental sunflower,S681.9
  11. Insulin Promotes Proliferative Vitality and Invasive Capability of Pancreatic Cancer Cells Via Hypoxia-inducible Factor 1α Pathway,R735.9
  12. Migration of VSMC and SPC by Expression of Sdf-1αin VSMC on the Effect of ox-LDL,R363
  13. Heterogeneity of Mitochondria in Systemic and Pulmonary Vascular Smooth Muscle Cells,R363
  14. Study on the Role of Poly(ADP-ribose)polymerase-1 in the Transcriptional Regulation of Vitamin D Receptor in Rat Thoracic Aortic Smooth Muscle Cells,R541
  15. Effect of STAT1-shRNA-mediated Gene Silencing on Biological Characteristics in the Cervical Cancer Cell Line Hela,R737.33
  16. Taurine and L-carnitine Synergistically Inhibit the Proliferation and Osteoblastic Differentiation of Vascular Smooth Muscle Cells,R543.5
  17. Overexpression ANT1 Gene in Vascular Smooth Muscle Cells Induced Apoptosis with Bax/Bcl-2 Expression Relations,R541.4
  18. Table oxide soluble hydrolase in coronary atherosclerosis lesions and its significance,R543.5
  19. Effects of Igf-Ⅰ and MGF on the Proliferation and Migration of Muscle Satellite Cells in Vitro,R329
  20. Experimental Study on Effects of Allicin on Proliferative Rabbits’ Vascular Smooth Muscle Cells Induced by Homocysteine,R285.5
  21. Amlodipine on LDL oxidation induced bone marrow progenitor cells injury,R965

CLC: > Medicine, health > Internal Medicine > Heart, blood vessels ( circulatory ) disease > Vascular disease > Carotid,venous diseases
© 2012 www.DissertationTopic.Net  Mobile