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The Cognitive Change among Successful Aging and Correlative Factors

Author: FangFang
Tutor: WuWenYuan;LiChunBo
School: Tongji University
Course: Psychiatry and Mental Health
Keywords: Successful Aging Cognitive function Neuropsychological tests Gene polymorphism Aging
CLC: R749
Type: Master's thesis
Year: 2005
Downloads: 118
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Objective: To explore successful aging, normal aging and pathological aging of the differences in the characteristics of the three cognitive aging process and some of its related factors. Subjects and methods: 1, the study sample derived from the Putuo District Shiquan and Oasis neighborhoods and communities of elderly people over the age of 65. Baseline completed a total of 421, were successful aging (successful aging, SA) group of 230 normal aging (usual aging, UA) group 137, 54 with mild cognitive impairment (mild cognitive impairment, MCI) group. Each set of standards based on the Chinese version of the Mini Mental State Examination (Chinese version Mini-mental Status Examination, MMSE) (stratified by level of education), activities of daily living (Activity of Daily Living, ADL) score value divided groups old per capita exclude significant physical illness. Complete the follow-up of a total of 156 cases, including the SA group 73 cases, UA 57 patients, MCI group 26 cases. 2, all the objects in 2003 and 2005, respectively, neuropsychological and psychological condition assessment. Research tool using Chinese elderly neuropsychological tests (Neuropsychological Test Battery for Elderly, NTBE) and Shanghai Elderly Population Health Questionnaire S.A.2002 \By polymerase chain reaction - restriction fragment length polymorphism (Polymerase chain reaction-Restriction fragment length polymorphism, PCR-RFLP) determination of apolipoprotein E (Apolipoprotein E ApoE) and angiotensin-converting enzyme (Angiotensin-converting enzyme, ACE) gene polymorphism. 3, according to the characteristics of data distribution, the use of the single factor and multivariate statistical methods to carry out a detailed analysis of the data, application SPSS11.5 and SAS6.12 completion of the statistical process. Results: 1, baseline: (1) controlling for age, gender, education level, successful aging group in NTBE the each subtest in most projects are significantly better than the MCI group, and significantly better than the normal aging group in a number of projects normal aging; no significant difference among the three groups learning effect index. (2) to carry ApoEε4 allele group not carrying the ε4 group compared to carrying the ACE D allele group compared to not carry the D group, have a number of neuropsychological tests, there were significant differences. Follow-up: (1) the MCI group part of the test completion rate difference was significantly lower than that of the SA and UA group; (2) follow-up neuropsychological test differences in the nature of projects decreased (18 vs 32); successful aging in delayed recall and long-term memory retrieval significantly better than normal aging. 3, the follow-up before and after the change: (1) Aging' dissertation">Successful Aging in immediate memory, delayed recall, cognitive aging slowdown in long-term memory retrieval, and perceptual motor speed, executive function decline more pronounced; normal aging in working memory, executive function decreased significantly; the MCI scores dropped fewer projects. Grouped by age, most of the neuropsychological tests declined most significantly in the 71 to 75 age group. (2) somatic activity, psychological status and self-efficacy are part of the neuropsychological tests, especially in the field of executive function, was significantly associated. (3) to carry ApoEε4 allele group and carrying the ACE D allele group in executive function projects is poor. Conclusions: (1) the integration of successful aging high cognitive level brain function and effective compensatory, compensatory strategies successful aging intervention. (2) cognitive aging process function is susceptible areas of cognitive function, and may affect the biological, psychological factors play the role of the mediator. (3) 71 to 75-year-old is a sensitive period of cognitive aging. (4) normal aging, mild cognitive impairment of cognitive function of the elderly remain in a certain plasticity of successful aging intervention has practical significance.

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