Dissertation > Excellent graduate degree dissertation topics show

Study on Magnetic Nanomicells Applied in Drug Controlled Release System

Author: HuangChi
Tutor: ZhouShaoBing
School: Southwest Jiaotong University
Course: Biomedical Engineering
Keywords: Nanomicelles The drug targeting system Cancer treatment
CLC: TB383.1
Type: Master's thesis
Year: 2011
Downloads: 141
Quote: 0
Read: Download Dissertation

Abstract


In this thesis, synthesis of superparamagnetic nanoparticles (SPIONs) was prepared on the basis of a series of magnetic nano-micelles. They are made from SPIONs, biocompatible polymer polyether type F127, F127 and the polylactic acid copolymer (F127-PLA), targeting ligand (folic acid) composition. By an infrared spectrophotometer (FT-IR), X-ray diffraction (XRD), vibrating sample magnetometer (VSM), dynamic laser light scattering (DLS), transmission electron microscopy (TEM) and atomic force microscopy (AFM ) of the series of the magnetic micelles were characterized. First, by coprecipitation of SPIONs, they can be stably dispersed in the oil phase, superparamagnetic and high saturation magnetization. Second, by chemical grafting method biocompatible F127 and F127-PLA polymers with SPIONs connected to the composite nanoparticles in an aqueous phase to form micelles by self-assembly. Used anticancer drug doxorubicin hydrochloride (DOX · HCl) as a model drug to study the in neutral, acidic, and the magnetic alternating magnetic field in vitro drug release micelles. At the same time series with Alamar blue method for magnetic nano-micelle biocompatibility evaluation, and drug-loaded micelles were inhibition of tumor cell antiproliferative materials evaluated. The results show that the magnetic micelles has good biocompatibility, when carrying drugs, the growth of tumor cells significantly inhibited. Finally, the magnetic nano-micelles in drug delivery system limitations, the subject of the magnetic micelles based on grafting of active targeting ligands - folic acid. Such targeted magnetic nanoparticles for targeted drug delivery systems micelle has a dual targeted (ie: folate targeting and magnetic targeting). When used as a cancer treatment drug carrier, can improve drug utilization and the drug delivery to the tumor site accuracy. Selection DOX · HCl as a drug model in neutral, acidic effect of magnetic micelles in vitro drug release behavior. Evaluating with Alamar blue micelles contained in different conditions inhibition of tumor cells in a magnetic field test proved download micelles containing folate ligand has a stronger inhibition of tumor cells. Vivo animal experiments show that the drug-loaded micelles targeted under the guidance of an external magnetic field, the legs of New Zealand White rabbits with VX2 tumor tumor site can be more accurate positioning, and tumor tissue has obvious therapeutic effect. In summary, this series of papers prepared micelles as drug carriers in the biomedical field has potential applications.

Related Dissertations

  1. Studies Toward Synthesis of Melphalan Hydrochloride,TQ463.2
  2. Angiostatin on the Cural Effect of H22 Liver Cancer in Mice and the Immune Influence of T Cell,R735.7
  3. A Pulmonary Embolism Patient with Chorion Cancer,R563.5
  4. The Treatment of Prostate Cancer (Report of 76 Cases),R737.25
  5. Fabrication of Degradable Polymeric Nanoparticles and Their Applications as Drug Delivery System,TQ460.1
  6. Investigation of Antitumou Effect on Rabbit Cheek Vx-2 Carcinoma in the Combined Treatment of Laser and 5-FU Sustained-release Dosage,R739.8
  7. Biological Effects of Magnetic Field on K562 Cell Lines and VX2 Cell Lines,R733.7
  8. Exper Study the Significance of Mutant P53、 P170 in Salivary Adenoid Cystic Carcinoma(SACC),R739.8
  9. Tyrosine kinase inhibitors AW1 Synthesis and pharmacological activity,R96
  10. Enzymatic synthesis of amphiphilic block copolymer micelles and their research,O631.3
  11. Traditional Chinese Medicine to reduce Ⅱ, Ⅲ of colorectal cancer recurrence and metastasis after the outcome of clinical series of studies to explore,R735.3
  12. The Current Research Status in TCM and Clinical Epidemiological Investigation on Breast Cancer,R273
  13. Measurement and Numerical Simulation in High Intensity Focused Ultrasound Transducer,R318.6
  14. Structural Design and Fabrication, Property Manipulation and Application of Zero-dimensional and Related Advanced Nanostructures,O481
  15. Studies on the Cell Cycle Arrest and Apoptosis Induced by Tetrazolium Violet in C6 and C127 Cancer Cells,R730.5
  16. Series-parallel high-intensity focused ultrasound tumor therapy machine 3PRS institutional performance analysis and kinematic calibration,TH789
  17. Design, Synthesis and structure analysis based on tumor-associated carbohydrate antigen glycopeptide derivatives,R914
  18. Study on Mechanism of Anti-tumor Effect by Ginsenoside Rg3,R285
  19. The Study of Constructing the Adenovirus Vectors Expressing the Soluble Ectodomain of TGF-βRⅡ and RANTES Gene and then Combined Using in Anti-Cancer Experiments,R73-36
  20. Research into Professor Zhou Zhongying’s Academic Experience of Treating Bronchopulmonary Carcinoma,R249.2

CLC: > Industrial Technology > General industrial technology > Materials science and engineering > Special structural materials
© 2012 www.DissertationTopic.Net  Mobile