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Preparation of magnetic targeting drug carrier and chelating properties of rhenium

Author: GengJingJing
Tutor: LiFengSheng；JiangZuo
School: Nanjing University of Technology and Engineering
Course: Materials Processing Engineering
Keywords: Magnetic targeting drug carrier Cobalt ferrite Magnetic chitosan microspheres DTPA TTHA Rhenium
CLC: TB383.1
Type: Master's thesis
Year: 2008
Downloads: 82
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Abstract


In this thesis , Preparation of magnetic targeting drug carrier , modified and rhenium chelating properties . By solid state reaction prepared spherical magnetic nanoparticles of cobalt ferrite magnetic core ; cobalt ferrite as biodegradable materials chitosan as skeleton material was prepared magnetic chitosan microspheres . With IR, SEM, TEM, XRD, TG-DSC, BET , and VSM testing means to characterize the structure and performance of magnetic nuclear magnetic chitosan microspheres . The results show that : the successful preparation of a particle size of about 20nm , than the saturation magnetization 52.78emu g -1 nano cobalt ferrite meet the requirements as a drug carrier magnetic core ; magnetic chitosan microspheres ball good , smooth surface , 23.96emu · g -1 , with a good magnetic response than the saturation magnetization . Selection of diethylenetriamine pentaacetic acid (DTPA) and triethylenetetramine acid (TTHA) on the surface of the magnetic chitosan microspheres modified . The characterization results show successful in the surface of the magnetic chitosan microspheres connection reactive carboxyl groups , and the modified spherical microspheres complete ; DTPA and TTHA modified magnetic chitosan microspheres than the saturation magnetization , respectively 21.42emu · g -1 , and 21.83emu g -1 , reduce the proportion of the magnetic response . Rhenium instead to the stability of the radionuclide radionuclide rhenium-188 , as a model ion chelating properties of the two types of modified magnetic chitosan microspheres with rhenium , and optimize their respective optimal reaction conditions and the maximum chelation The Hopewell rate . The results showed that in their respective optimal reaction conditions , diethylenetriamine pentaacetic acid - modified magnetic chitosan microspheres with rhenium chelation rate can reach more than 90% , triethylenetetramine acid modified magnetic chitosan microspheres and rhenium chelate was about 60%.

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