Dissertation > Excellent graduate degree dissertation topics show

Transition-metal Catalyzed Reactions of Enynes and Study Toward Synthesis of Indole Alkaloids: Minfiensine and Phalarine

Author: ZhangYongQiang
Tutor: TuYongQiang
School: Lanzhou University
Course: Organic Chemistry
Keywords: Transition metal Enyne compounds Indole alkaloids Minfiensine Phalarine
CLC: O621.36
Type: PhD thesis
Year: 2011
Downloads: 41
Quote: 0
Read: Download Dissertation


Enyne compound as an important reaction in organic synthesis block, to study the synthesis of new chemical conversion and applied to the natural product is one of the important research in organic chemistry. This subject, This thesis describes enyne a new chemical compound in the transition metal such as Au, Pd-catalyzed conversion, and by transition metal catalyzed enyne compound tandem reaction in the form of the natural product Minfiensine total synthesis, and finally introduced the work done by the author Phalarine synthesis study. Include the following five aspects: a. Discovered Au (Ⅰ) compounds as a Lewis acid-catalyzed enyne alcohol condensation reaction, a special class structure jump more than enyne compound. Using the product intramolecular Diels-Alder reaction and the thermal cyclization reaction, gives useful for organic synthesis of the thiophene [f] inden-structure compounds and multi-substituted allene compounds, and a class of multi-substituted thiophene [f] indene The compounds developed into fluorescent probes for the detection of mercury ions. . Development of a class of Au (Ⅰ) catalyzed indole protecting group control indole indole the acetylenic compounds regional selective cyclization reaction. When the protecting group is an electron donating group, obtained by reacting a class of pharmaceutical chemistry very important the substituted tetrahydro carboline compound; when the electron withdrawing group, the reaction to m-class exists in the natural product false oxidation indole structure compound provides a new approach for the synthesis of such alkaloids. More importantly, through the regulation of the indole protecting group is achieved indol C2, C3 is a nucleophilic reaction selectivity. III. The acetylenic compounds through the Pd-catalyzed ene Tsuj i-Trost / hydrogen amination / 1,3-H migration tandem reaction, the development of a synthetic multi-substituted pyrrole-effective method. The acetylenic compounds Au (Ⅰ) catalyzed indole indole enyne cyclization / imine positive ion cyclization tandem reaction as a key step in and build a the indole alkaloids Minfiensine the tetracyclic core fan-shaped skeleton, further implement the natural product in the form of total synthesis. Design series by Au (Ⅰ) the acetylenic compounds catalyzed indole enyne cyclization / Friedel-Crafts reaction as a key step synthesized the indole alkaloids Phalarine synthesis strategy and a useful attempt. This work has not been completed, to deepen our understanding of the reactivity of the indole and provide a useful inspiration the completed Phalarine synthesis.

Related Dissertations

  1. The Synthesis, Structure Research of Scorpionlike Dis-pyrazoly-Pyridine and Its Coordination Complexes,O621.13
  2. Synthesis and Characterization of Lanthanide Ions and Cu (Ⅰ/Ⅱ) Complexes Based on Keggin Polyoxometalate Anions,O641.4
  3. The Theoretical Foundation and Current Situation of the Research on Optical and Magnetic Properties of 3d Transition-metal Ions,O469
  4. Synthesis, Crystal Structure and Properties of Porous Metal-Organic Frameworks Constructed from Bispyridines Ligands,O621.13
  5. Self-assembly of Coordination with Flexible Ligand 1, 3, 5-tri(Triazol-1-ylmethyl)-2, 4, 6-trimethylbenzene,O621.13
  6. Synthesis, Structure and Characterization of Inorganic-Organic Hybrid Compounds Based on Polyoxotungstates,O611.3
  7. Synthesis, Structures and Properties of Metal Complexes with Polypyridine-like Ligands,O621.13
  8. The First Principle Study of Methane Adsorption and Reaction on Transition Metal Surfaces,O647.31
  9. Microwave Magnetic Properties of 2:17 Rare Earth-3d Transitionmetal Intermetallic Compounds Powders/resin Epoxy Compolites with Planar Magnetic Anisotropy,O482.54
  10. Study of Salen-transition Metal Complexes Synthesis and Interaction with DNA,O621.13
  11. Synthesis and Characterization of Multi-dentate Ligands Containing N and S Heteroatoms and Their Transition Metal Complexes,O621.13
  12. Gas Phase Reaction Mechanism of ZrO+ with CS2、NbS+ with H2O and N2O with H2 Cyclically Catalyzed by Ir+,O643.12
  13. Preparation and Investigation on Photocatalytic Reactivity of Transition Metal Lon Doped TiO2,O643.36
  14. Syntheses, Structure and Properties of Transition Metal Complexes with β-diketone Derivative Ligands,O641.4
  15. Synthesis, Crystal Structures and Properties of Transition and Lanthanide Metal Complexes Constructed by (Iso) Nicotinic Acid,O641.4
  16. Synthesis, Crystal Structure, and Characterization of Transition-Metal Complexes Based on Oxomolybdate Building Blocks,O641.4
  17. Studies on Selective Control of Transition Metal-Catalyzed Reactions,O621.3
  18. Effect of Transition Metal Oxides and Chemical Bleaching Process on the Whiteness of Kaolins,TD985
  19. A new three teeth secondary amine ligands and their complexes Synthesis, Characterization and Properties,O641.4
  20. Nickel, copper -catalyzed coupling reagents heterocyclic boronic acid as direct arylation,TQ203.2
  21. Preparation and Properties for the Energy-saving Infrared Radiant Coatings,TQ630.7

CLC: > Mathematical sciences and chemical > Chemistry > Organic Chemistry > Organic Chemistry general issues > Synthetic organic chemistry > Heavy organic synthesis or catalytic organic synthesis
© 2012 www.DissertationTopic.Net  Mobile