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Studies on the Liposomes of Ascorbic Acid Organic Germanium Sesquioxide

Author: GaoZuoZuo
Tutor: ZuoJing
School: Heilongjiang University of Traditional Chinese Medicine
Course: Pharmaceutical Analysis
Keywords: Ascorbic acid, organic germanium sesquioxide Liposomes Preparation Process Calcium acetate gradient method
CLC: R943
Type: Master's thesis
Year: 2011
Downloads: 20
Quote: 0
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Abstract


The experiments using calcium acetate gradient prepared ascorbic acid liposomes, organic germanium sesquioxide Method for determination of content and entrapment , and its physicochemical properties and stability . The experimental main findings are as follows : 1 . Organic germanium sesquioxide content and entrapment efficiency UV spectrophotometric determination of ascorbic acid in liposomes . Ascorbic acid organic germanium sesquioxide a good relationship in the concentration range of 40 ~ 140μg · mL-1 inside . 2. Ascorbic organic germanium sesquioxide liposome preparation methods and process conditions . First of ascorbic acid on the oil / water partition coefficient of organic germanium sesquioxide visits; film dispersion method , the ethanol injection method , ether injection method , reverse phase evaporation method , calcium acetate gradient method five liposome preparation methods were screened determined based on the encapsulation efficiency of calcium acetate gradient method for the preparation method ; orthogonal design L9 (34 ) , evaluation of the encapsulation efficiency was the process of preparation of calcium acetate gradient method optimization , optimization of the resulting liposomes encapsulation efficiency was 84.12% , evenly rounded under a transmission electron microscope , the average particle size of 111.6nm . Preliminary results of the stability studies : ascorbic acid, organic germanium sesquioxide liposomes are relatively stable when stored at 4 ℃ . 4 draw the release curve , the results show that ascorbate organic germanium sesquioxide liposomes in PBS no burst release , the general laws of the liposomes . The experimental results show that the prepared calcium acetate gradient liposomes , and the particle size found targeting requirements, to achieve a target of the present experiment . Ascorbic acid, organic germanium sesquioxide liposome is expected to further in vitro experiments , animal experiments and clinical testing the drug as an anticancer drug .

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