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Synthesis of New Chalcone Derivatives Containing Heterocyclic Moiety with Potential Antibacterial Activity

Author: ChenZhenHua
Tutor: PuHuRi
School: Yanbian University
Course: Medicinal Chemistry
Keywords: Chalcone Heterocyclic Antibacterial activity
CLC: R96
Type: Master's thesis
Year: 2011
Downloads: 29
Quote: 0
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Abstract


At present, the share of the world's population, a large proportion of the total number of deaths due to bacterial diseases has led to the death . At this stage to use a variety of antimicrobial susceptibility gradually reduced , leading to the surge in the number of drug-resistant pathogens and microbial , especially Gram-positive bacteria . Treatment of infection Methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) patients is another challenge faced by the medical profession . In addition , patients infected with the AIDS virus , has received anti-cancer treatment or transplantation of organs of patients , their immune suppressed , makes for their treatment of bacterial diseases become more complex . In view of the global clinical resistant strains spread rapidly and the phenomenon of cross-infection between resistant flora , the discovery and optimization of inhibition of drug-resistant strains of antimicrobial agents is crucial . To synergistic antibacterial activity of chalcone and heterocyclic compound having chalcone and heterocyclic structure were synthesized and tested for its antibacterial activity . The results show that some compounds have greater antibacterial activity against Gram - positive bacteria , and in particular the multi-resistant bacteria . These compounds have efficient antibacterial activity against Staphylococcus aureus , derivatives 6k activity reached 2μg/mL to control drug norfloxacin quite better oxacillin . 6a-s , and the two series of compounds 8a-o 64μg/ml concentration conditions , the Gram-negative bacteria Escherichia coli CCARM 1924 or the growth of Escherichia coli CCARM 1356 is not inhibited. Thesis synthesized compounds were confirmed by IR, 1H-NMR, MS .

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CLC: > Medicine, health > Pharmacy > Pharmacology
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