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Effects of Different Load Swimming on Nonenzymatic Glycosylation in Aged Mice Induced by D-galactose

Author: ZhangRuiTao
Tutor: CuiYuPeng
School: Capital Institute of Physical Education
Course: Human Movement Science
Keywords: Swimming D- galactose Non-enzymatic glycosylation Aging rats
CLC: R87
Type: Master's thesis
Year: 2011
Downloads: 36
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Abstract


Objective: for anti-aging research focus on sports, inspection on moving anti-aging and non-enzymatic glycosylation literature at home and abroad, a preliminary understanding of the relationship between them. In this study, animal experiments, through the establishment of D-galactose subacute aging rat model, as different load swimming interventions, observed changes in rats athletic ability and detection of skeletal muscle, lung, liver, heart and serum AGEs content explore the impact of different load swimming exercise on aging rats non-enzymatic glycosylation, anti-aging movement theory and research to provide a scientific experimental basis. Methods: The experiment: a swimming training on D-galactose aging rats impact study of non-enzymatic glycosylation. 40 healthy male SD rats were randomly divided into four groups: sedentary control group (SA) 10 only D-half-the lactose induced aging control group (YA) 10, D-galactose induced aging swimming training 45min (YT) 10, D-galactose induced aging swimming training 90min group (YH) 10; in accordance with the design of experiments on rats D-galactose induced aging model, modeling time of eight weeks, half of the D-model lactose to the aging group regular daily injection of D-galactose solution (125mg/kg body weight), the control group was injected with normal saline. After the completion of the model, a one-time exercise immediately after taken for the determination of rat heart, lung, liver, skeletal muscle, serum in AGEs, MDA, GSH, CAT, SOD content or activity. Experiment II: surrounded by swimming training on D-galactose aging rats the impact of non-enzymatic glycosylation. 40 healthy male SD rats were randomly divided into four groups: sedentary control group (SAF) only D-galactose induced aging control group (YAF) 10, D-galactose induced aging swimming training 45min (YTF) 10, D-galactose induced aging swimming training 90min (YHF) = 10; accordance with the design of experiments on rat D-galactose induced aging model (the specific method of the same experiment). The modeling is complete, surrounded by swimming training, 24 hours after the last training drawn for determination of rat heart, lung, liver, skeletal muscle, serum AGEs, MDA, GSH, CAT, SOD content or activity. Research Results: 1 After a swimming training, the rats body weight between regular changes (P> 0.05); 2.MDA changes, heart, liver, skeletal muscle were tested YH group> YA group> YT group order, serum, lung YA group should higher than YT, YH group, the SA group in the five organs and tissues are the lowest, and the hearts of YA group P lt; 0.05 serum YA group P lt; 0.05 ; 3.CAT changes, heart, lung, liver YT group> YA group> YH group, skeletal muscle YH, YT group is greater than the the YA groups (P> 0.05); 4.SOD changes, lung, skeletal muscle, serum SOD activity were tested YT group> the YA group> YH group, lung, skeletal muscle YT group YH group has a significant difference (P lt; 0.05), hearts YA group than YH, YT group has significant difference ( P lt; 0.05); 5.GSH changes, heart, skeletal muscle, serum GSH levels were tested YT group> YH group> YA group, and the heart, serum the YT group and YA group had significant changes (P lt; 0.05), lung, liver GSH content were tested YT group YA group> YH group (P gt; 0.05); 6.AGEs changes, heart, lung, liver, skeletal muscle of AGEs content YT, YH group than YA group, and lung, liver YT group compared to the YA group had significant difference (P lt; 0.05), serum AGEs content was the YT group of YA group> YH group (P GT; 0.05) Experiment II, 1. After four weeks training, body weight of rats in each group were the YTF groups YHF group> YAF group (P> 0.05); 2.MDA changes, heart, lung, skeletal muscle, serum MDA content YTF YHF group less than the YAF group, and in the lung with YHF group than there were significant differences (P lt; 0.05), MDA content in the liver or was YHF> the YAF group YTF (P gt; 0.05); 3.CAT change, the heart , lung, skeletal muscle CAT activity YTF YHF group than the YAF group, CAT activity changes in the liver was YHF group YAF group YTF group (P GT; 0.05), serum CAT activity YTF YHF group than YAF group (P gt; 0.05); 4.SOD changes, heart, lung, skeletal muscle, serum SOD activity YTF YHF group than the YAF group, and the lungs YHF group YAF group significant difference ( YHF P lt; 0.05), liver SOD activity was the YTF group> YAF group> (P gt; 0.05); 5.GSH changes, heart, lung, liver, skeletal muscle, serum GSH content YTF, YHF group than the YAF group and YHF group YAF of the lung, there was significant difference (P <; 0.05) compared YTF serum group YAF There was significant difference (P lt; 0.05) compared; 6.AGEs change, heart, lung, liver, skeletal muscle, serum AGEs content YTF YHF group than the YAF group, hearts YHF group compared with the YAF group there was significant difference (P lt; 0.05), the lungs of AGEs content YTF group with YHF, the YAF group compared low to have a significant difference (P lt; 0.05). Conclusions: Graded Swimming (t = 45min, 90min) can be adjusted in aging rats non-enzymatic glycosylation role in maintaining the stability of the antioxidant system, the role of aging. ; Graded Swimming (t = 45min, 90min) can enhance the the aging rat body's antioxidant capacity; 3 different load swimming (t = 45min, 90min) can enhance the aging rats body of non-enzymatic sugar group of the role of inhibition. 4, weight changes only as supplementary indicators of the movement of animal anti-aging observed.

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