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The Expression and Clinical Significance of AIF、HSP70 and SURVIVIN in Gastric Cancer

Author: WangZuo
Tutor: FanZhongZuo;WangXueHong
School: Qinghai University
Course: Internal Medicine
Keywords: Gastric cancer AIF SURVIVIN HSP70 Immunohistochemistry
CLC: R735.2
Type: Master's thesis
Year: 2011
Downloads: 11
Quote: 0
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Abstract


Objective To study the Qinghai region the AIF, SURVIVIN and HSP70 expression in gastric cancer and normal gastric mucosa and its role in the development of gastric cancer . Designed to study the role and significance of the three in the development of gastric cancer . Collected 60 patients with gastric carcinoma and 60 cases of normal gastric mucosa , two-step detection by immunohistochemistry AIF , SURVIVIN and HSP70 expression in gastric cancer and normal tissues , and observed both with age , gender , lymph node transfer , the relationship between tumor grade and TNM staging . Results of gastric cancer tissues AIF , SURVIVIN and HSP70 immunohistochemistry scores were higher than the normal gastric mucosa , and the difference was statistically significant ( P lt; 0.01 ) ; the AIF, SURVIVIN and HSP70 protein expression in different age and gender group differences was not statistically significant (P gt; 0.05); AIF expression in different stages , whether the transfer as well as the degree of differentiation of tumor cells showed no statistical significance ( P gt ; 0.05) ; patients with gastric cancer phase II and phase III of HSP70 protein integral were higher than phase I , and the difference was statistically significant ( P lt; 0.01 ) ; the patients III gastric cancer tissue SURVIVIN protein integral higher than phase I , and the difference was statistically significant ( P lt; 0.05 ) ; poorly differentiated group gastric tissue the HSP70 protein points higher than the well-differentiated group , and the difference was statistically significant ( P lt; 0.01 ) ; poorly differentiated group with well-differentiated gastric carcinoma tissue compare SURVIVIN proteins integral difference was not statistically significance ( P gt ; 0.05) ; without lymph node the metastasis HSP70 and SURVIVIN protein scores were lower than patients with lymph node metastasis , and the difference was statistically significant ( P lt; 0.05 ) . Respectively SURVIVIN AIF and HSP70 protein expression was positively correlated (r = 0.520 and 0.772 , respectively ) , the expression of HSP70 and AIF was also positively correlated (r = 0.568). AIF in the conclusions of gastric carcinoma , the high expression of survivin and HSP70 participate in gastric carcinogenesis , development , condition assessment and prognosis of gastric certain sense , can be used as a reference index to predict gastric malignancy and prognosis .

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CLC: > Medicine, health > Oncology > Gastrointestinal Cancer > Gastric neoplasms
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