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Macrostructure of Sleep in Patients with Vascular Cognitive Impairment-no Dementia

Author: ZhuMuFeng
Tutor: DengLiYing
School: Nanchang University
Course: Neurology
Keywords: vascular cognitive impairment-no dementia polysomnography cognition disorder
CLC: R749.1
Type: Master's thesis
Year: 2011
Downloads: 35
Quote: 0
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Abstract


Objective:To investigate the sleep structure in patients with vascular cognitive impairment-nodementia(VCI-ND) and its differences from that of normal individuals.Methods:Twenty inpatients and outpatients examined in our department and consistent with the 2007 Chinese consensus on vascular cognitive impairment were send to our study, the age of these subjects was 64.35±6.42y (55～80y).Sleep quality was assessed by sleep scale questionnaire and the whole night sleep record of 20 patients with VCI-ND were monitored by 32-head video-taped polysomnographic system, and the results were compared with the data of 20 normal subjects.Result:Compared with normal subjects, worse subjective sleep quality and impaired daytime function can be observed in patients with VCI-ND, Pittsburgh Sleep Quality Index scales of VCI-ND group and control group was 8.65±0.9947and 3.60±1.3870 (P<0.001),respectively. Epworth Sleepiness Scale was 8.15±1.9808 and 4.35±2.1588 (P<0.001),respectively. Total sleep time(TST) of VCI-ND group and control group was decreased to 267.10±58.0582 and 414.50±87.8340 (P< 0.001),respectively, sleep latency(SL) was decreased to 33.40±2.6288 and 23.45±1.4770 (P<0.001); apperception time(AT) was increased to 6.40±1.7592 and 5.15±1.6631 (P<0.05); wakefulness(WASO) was increased to 170.88±9.4045 and 103.60±8.3250 (P<0.001); proportion of stage I sleep(S1%) was increased to 48.15±2.3484 and 14,03±0.6644 (P<0.001), while proportion of stageⅡ,Ⅲand IV sleep(S2%,S 3-4%) was decreased, S2(%)was 32.88±1.2204and 59.96±1.1134, S3-4 (%) was 1.93±0.6494 and 4.09±0.7614, rapid eye movement sleep (REM) was decreased to 16.86±0.9429 and 21.93±0.8067, and sleep quality was decreased to 57.80±2.0157 and 77.35±1,2258, respectively.Conclusion Increased light sleep as well as decreased slow-wave stage 3-4 sleep and decreased rapid eye movement stage (REM) observed in our patients may be a specific electroneurophysiologic marker in patient with vascular cognitive impairment-no dementia, however, a large-sampled multi-centered randomized controlled trial is necessarily to confirm whether it can be used as specific diagnostic marker for screening and early diagnosis in clinical practice.

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