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Background is pentameric protein -3 (Pentraxin-3, PTX-3) is a recent study found that an acute inflammatory phase protein containing 382 amino acids pentamer structural proteins belonging to the C-reactive protein (CRP) superfamily members. PTX-3 expression in the inflammatory cytokines tumor necrosis factor, interleukin-1 induced by vascular endothelial cells and macrophages. Acute coronary syndrome (acute coronary syndrome, ACS) serum PTX-3 levels significantly increased. Dyslipidemia is a major risk factor for coronary heart disease (CHD). Reported in the literature PTX-3 in atherosclerotic plaques apparent expression, suggesting that the PTX-3 levels may more directly reflect the inflammatory state of the blood vessels, are referred to as the vasculature \correlation with lipids, hs-CRP level for further study. Objective To detect the serum of patients with ACS PTX-3 level, analysis of its correlation with blood lipids, hs-CRP, investigate serum PTX-3 lipids combination predictive value for detection of ACS prognosis. Method randomly collected and analyzed from July 2008 to December 2009, 146 cases in the Department of Cardiology, Second Xiangya Hospital, Central South University of hospitalization in patients with coronary heart disease, the patients were divided into stable angina (stable angina pectoris, SAP) and ACS group select group, health examination center in the same period 25 cases of healthy adults as a control group. Enzyme-linked immunosorbent assay (ELISA) in serum of subjects PTX-3 levels, analysis of serum PTX-3 and serum lipids, hs-CRP correlation. In addition, ACS patients were followed up for 3 months, and is divided into two subgroups PTX-3 abnormal group and the normal group of PTX-3, the predictive value of serum PTX-3 and lipid levels on the prognosis of ACS. Results 1 ACS patients serum PTX-3 levels significantly higher than the SAP group and normal control group (6.39 ± 3.01 ng / ml compared with 3.87 ± 2.05 ng / ml, 2.90 ± 1.94 ng / ml, P lt; 0.01) differences were significant; patients with total cholesterol / high-density lipoprotein (TC / HDL-C) level in ACS group was significantly higher than the SAP group and the normal control group (5.00 ± 1.60 vs 4.21 ± 1.50,2.93 ± 0.60, P lt; 0.05) , the differences were statistically significant. Serum PTX-3 level difference between SAP group and normal control group was not statistically significant (3.87 ± 2.05 ng / ml the ratio 2.90 ± 1.94ng/ml, P gt; 0.05), TC / HDL-C difference was statistically significance (4.21 ± 1.50 vs 2.93 ± 0.60, P lt; 0.05). 2, serum PTX-3 with hs-CRP predicts ACS ROC curve analysis can be seen that the area under the ROC curve of serum PTX-3 levels of 0.77, the area under the curve of hs-CRP 0.65, the area under the curve is greater than 0.5, two by the diagnosis of ACS has a certain value. Serum PTX-3 levels in patients with ACS diagnosis sensitivity and specificity were 72.6% and 70.6%, respectively. Serum hs-CRP levels of patients with ACS diagnosis sensitivity and specificity were 54.2% and 62.5%, respectively. ACS patients serum PTX-3 and TG / HDL-C, TC / HDL-C, TG, TC, hs-CRP no significant correlation (r values ??were 0.14,0.01,0.11,0.02,0.12 P value are gt; 0.05). Serum PTX-3 correlation (r = -0.16, P = 0.04), LDL-C and HDL-C correlation (r = 0.23, P = 0.01), the differences were statistically significant. ACS serum PTX-3 increase group compared with the normal group, the incidence of adverse coronary events in the past three months was significantly higher, the difference was statistically significant (OR = 3.00, P lt; 0.05). TC / HDL-C increased group compared with the normal group, the past three months, the incidence of adverse coronary events was significantly higher, the difference was statistically significant (OR = 2.71, P lt; 0.05); TC / HDL-C and PTX-3 were abnormal group than in the normal group of recent coronary event rate was significantly higher (OR = 6.13, P lt; 0.05). Conclusion 1, compared with SAP group and normal control group, the ACS serum PTX-3 and TC / HDL-C levels were significantly increased, suggesting that serum PTX-3 and TC / HDL-C level with plaque instability related. Serum PTX-3 can be used as a new ACS assessment indicators, and better than hs-CRP. ACS patients, serum PTX-3 and TC / HDL-C level increased by short-term prognosis is relatively poor, suggesting that serum PTX-3 or the TC / of HDL-C can be used as predictors recent ACS patients with poor prognosis, the United detect both help predict ACS patients with recurrent coronary events.
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