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Objective: This article from the literature review, theoretical discussion, experimental research Capsules for Prevention and Treatment of Diabetes fat level T2DM, IR more systematic study. The highlights intrahepatic inflammation in the pathogenesis of T2DM, IR, explore Yiqiyangyin, correlation the the circulation Xiezhuo Theory and T2DM, IR intrahepatic inflammatory pathogenesis. Diabetes capsule fat level by inhibiting intrahepatic NF-κB expression, thereby improving IR, and thus play a role for the prevention and control of T2DM play from the theoretical and experimental observed experimental study Chinese medicine in the prevention and treatment of T2DM, IR on edge. Methods: In this study, the establishment of T2DM rat model, divided into normal group, model group, the Diabetes lipid level capsule treatment group, maleate rosiglitazone treatment group. And immunohistochemical methods for the detection of glucose, lipids, CRP-related indicators, NF-κB expression in the liver tissue protein levels. Results: 1 Diabetes lipid level capsule can reduce the general state of the T2DM rats, hypoglycemic effect, with the the T2DM model group there was significant statistical significance (P lt; 0.01); can reduce the body weight of obese rats T2DM model group, there is a significant statistical significance (P lt; 0.01); reduce serum cholesterol (CHO), triglyceride (TG) role, compared with the DM model group with significant statistical significance (P lt; 0.01). Prompt Diabetes fat Capsule experimental T2DM rats have a role in the regulation of glucose and lipid metabolism. 2 Diabetes lipid level capsule can reduce the T2DM rat C-reactive protein levels, with the model group than those with significant differences. Prompt Diabetes lipid level capsule can improve the T2DM rats in vivo microinflammatory environment. 3 the T2DM rat liver tissue NF-κB protein expression: immunohistochemistry results showed that Diabetes fat Capsule group of NF-κB-positive reaction products are mainly expressed in Kupffer cell nucleus, the nucleus of the intrahepatic infiltrating inflammatory, hepatic lipid drops vesicle wall and a small number of liver cell nuclei, but the involvement of a number of cells and the staining intensity lower than the model group. Model group, NF-κB-positive reaction products are mainly expressed in Kupffer cell nucleus intrahepatic infiltration of inflammatory cell nucleus, hepatic lipid droplets vesicle wall and a small number of hepatocyte nuclear, strong staining, involving a wide range. Conclusion: Diabetes lipid level capsule has hypoglycemic, lipid-lowering, weight loss and improve the role of the IR. Elevated protein levels of NF-κB in the T2DM rat liver tissue, suggesting that NF-κB micro aspects of the pathogenesis of inflammation of the liver tissue of obese T2DM; Diabetes lipid level capsule can reduce the T2DM rat liver tissue NF- κB protein expression levels of NF-κB target of the herbal compound.
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