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Clinicopathological Research of Jugulotympanic Paraganglioma with Analysis of Prognostic Factors

Author: XuWeiQing
Tutor: WangZhengMin
School: Fudan University
Course: Otorhinolaryngology
Keywords: Neck tympanic paraganglioma Microsurgery Immunohistochemistry Vascular endothelial growth factor Estrogen Receptor Progesterone receptor Androgen receptor Prognostic factors
CLC: R739.61
Type: PhD thesis
Year: 2003
Downloads: 29
Quote: 1
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Abstract


Destination observation neck tympanic paraganglioma pathological changes and vascular endothelial growth factor, estrogen , progesterone and androgen receptor pathway and prognostic factors for neck tympanic paraganglioma . Observed object and method REVIEW sexual analysis of 33 cases of carotid tympanic Vice nerve section tumor clinical information , take which 17 cases archived pathological specimens , line hematoxylin prime - eosin and Envision method immune tissue chemical staining , and under an optical microscope observation on the immune organization The chemical results of the semi-quantitative grading . SPSS 10.0 for Windows software for statistical analysis of clinical data and the results of immunohistochemistry . 17 cases of pathological specimens are rich in capillaries and sinusoids , the invasion of bone tissue ; 17 specimens , 11 cases of expression of vascular endothelial growth factor, and Fisch grading positive correlation ( r = o.529 , p lt ; 0.05 ) ; 17 specimens expression of estrogen receptor, progesterone receptor and androgen receptor ; Logistic regression analysis showed that Fisch classification have a significant impact on whether or not the residual tumor regression coefficient beta = 1.798 , grading Fisch more high residual tumor . Conclusion neck tympanic paraganglioma rich in blood vessels , some aggressive ; neck tympanic paraganglioma expression of vascular endothelial growth factor , which may play a role in promoting tympanic paraganglioma in neck tumor ; found no neck tympanic paraganglioma expression of estrogen receptor, progesterone receptor and androgen receptor ; grading Fisch is an independent prognostic factor for carotid tympanic paraganglioma microsurgery .

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CLC: > Medicine, health > Oncology > Department of Otolaryngology tumor > Ear tumor
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