Dissertation > Excellent graduate degree dissertation topics show

The Oxytocin Receptor Studies and Research on Expressions of Neurotransmitters’ Receptors in Oxytocin- and Vasopressin-containing Neurons in Rat Hypothalamus

Author: JinLiang
Tutor: JuGong
School: Fourth Military Medical University
Course: Neurobiology
Keywords: Oxytocin Arginine vasopressin Acceptor Acetylcholine Nicotine Hypothalamic Neurohypophysis
CLC: Q42
Type: PhD thesis
Year: 2004
Downloads: 160
Quote: 2
Read: Download Dissertation

Abstract


Oxytocin (OT) is a nonapeptide neuroendocrine hormones, hypothalamus supraoptic the nuclear (Supraoptic nucleus of SO) in the central nervous system (Central nervous system, CNS), paraventricular nucleus (Paraventricular T nucleus of Pa) large cell endocrine neurons synthesis and release into the peripheral blood and neurohypophysis, acting on its target tissues such as breast and uterine smooth muscle to play to promote shoot milk (Milk eiection), promote contractions role of. In the CNS, OT distribution in the ovary, testis and epididymis and other reproductive organs, regulation of germ cell development from; addition, thymus, adrenal, and cardiovascular system, there are also the OT, and may have some physiological function . The traditional view, the OT limit the physiological function of promoting shot milk and promote contractions role. A recent study found that in addition to these effects, OT is also involved in regulating mammalian maternal behavior, mate choice behavior and social interactions, memory, and other activities. And, under a variety of physiological and psychological stress conditions, hypothalamic OT neurons are activated, and the release of a large number of OT into the outside of the Fourth Military Medical University doctorate On husband peripheral blood and brain nerve extracellular matrix. There is evidence that the increased concentration of brain OT after stress involved in the regulation of the hypothalamic-pituitary-adrenal axis (HyPothalamus-Pitutary-adrenal gland axis, the HPA axis). The various functions of OT from OT receptors (Oxytoein reeeptor, OTR) mediated. OTR is composed of more than one peptide chain G protein uncoupling seven transmembrane receptors, OT and OTR activation of phospholipase C-protein kinase C system, and ways to increase endogenous Ca2 concentration produce a series of biological effects. We cloned people OTR carboxyl-terminal fragment of the coding region and prokaryotic expression; addition, we cloned the full length of the coding region of human OTR, transient transfection of eukaryotic and COS-7 cells. OT can and arginine vasopressin (Arginine vasopressin, AVp) neurons Pa cells Ministry and almost the entire 50. Their spatial distribution is very close and have their own characteristics. The OT neurons basic expression OT, AVP neurons express only the basic AVP. Both neurons expression of cell surface receptors of a variety of neurotransmitters and neuromodulators, and accepts a variety of different sources of nerve fibers dominated, therefore, a variety of neurotransmitters or quenched and can affect the OT or AVP neurons The physiological function of the yuan. We used immunohistochemical methods a3 and / or a5 nicotinic acetylcholine receptor (Nicotinie acetyleholine reeeptor, N a AehR) subunits in rat hypothalamic OT neurons advantage-expression This is inconsistent with the eighties of the last century, the British scholar Mason conclusions similar work; And we also found that a3 and / or a5 N AChR subunit expression in OT neurons axons, this positive immune response axons has been extended to the end of the median eminence and neurohypophysis; seven days in the neonatal rat hypothalamus, a3 and / or a5-type N-AChR subunit distribution similar to adult mice. High osmotic stress in rat hypothalamus, a3 and / or a5 N AChR subunit advantage distribution does not change; while 50 dendritic increased expression of N the AchR like immunoreactivity's OT can . Interestingly, our immunohistochemical methods in rat hypothalamic large cell neurons, TP substance receptor (substanee P reeeptor, SPR), distribution is extremely similar to a3 and / or a5 N AChR Asia units, but also showed the advantages of distribution of the Fourth Military Medical University, Doctoral Dissertation in OT neurons and axons. We also used the method of embedding former ABC immuno-electron microscopy study of the SPR 50 and Pa OT neuronal ultrastructure distribution.

Related Dissertations

  1. Protective Effect of Ginsenoside Against Acute Renal Failure and Expression of ChAT-IR in the Lateral Magnocell of Hypothalamic Paraventricular Nuclei(PaLM),R285.5
  2. Effects of Estrogen on Proliferation and Differentiation of Human Embryo Mandibular Condylar Chondrocytes,R782.6
  3. Dorsolateral rat hypothalamic nucleus 5 - serotonin and 5 - HT 2A receptor expression,R338
  4. Phthalocyanine -based electron donor - acceptor assembly and performance of water photolysis,O643.32
  5. Hypertrophic scars CD90, Ⅰ, Ⅳ collagen and TGF-β Ⅰ type , Ⅱ-type receptor expression correlation analysis,R622
  6. NO Intervention of Carbon Disulfide Toxicity on the Reproductive Secretion Function of Hypothalamus -pituitary-testis Axis in Male Rats,R363
  7. Establishment of Vero Cell Line Stably Expressing CDV SLAM Receptors of Different Animals,S855.3
  8. The Effect of Chronic Intermittent Hypoxia on Hippocampus Relating Learning and Memory,R56
  9. The Preventive Effect of Misoprostol and the Oxytocin in Postpartum Hemorrhage,R714.461
  10. Nicotine on rat airway smooth muscle intracellular calcium concentration and membrane transient receptor potential channel TRPC expression,R563.9
  11. Correlation between Oxytocin Receptor and Pain in Patients with Endometriosis,R711.71
  12. Effects of Cholinergic Anti-Inflammatory Pathway on Ventilator-Induced Lung Injury,R563
  13. The Effects of Late Asthmatic Reaction in Rats Exposed to Different Concentrations of Sufur Dioxide,R562.25
  14. Expression of ER、PR and OTR in Placenta of Preeclampsia Patients,R714.2
  15. Behavioral and Electrophysiological Study of Arginine Vasopressin Against Aβ25-35-Induced Neurotoxicity,R749.16
  16. Studies on a New Anticongestive Heart Failure Drug Tolvaptan,TQ463
  17. Expression of SRC-1, ER, PR and Their Significance in Endometriosis,R711.71
  18. Coexistence of OT and GnRH in Hypothalamic-Pituitary-Ovary of Dairy Goat during Gregnancy,Q4
  19. The Effect of GnRH Analogue on Expression of Oxytocin in Hypothalamic-Pituitary-Gonad Axis and Learning and Memory in Mice,Q4
  20. The Distribution of Oxytocin and Ghrelin in the Hypothalamus of Mice and Its Relationship with Obesity,Q41
  21. Bioremediation of Petroleum Contaminated Soil Study,X53

CLC: > Biological Sciences > Physiology > Neurophysiology
© 2012 www.DissertationTopic.Net  Mobile