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A Study on Proteins Associated with Lymph Node Metastasis in Squamous Cell Carcinoma of the Lung Using High-throughput Approaches

Author: LinDongMei
Tutor: PanQinJing;GaoYanNing;ChengShuJun
School: Peking Union Medical College , China
Course: Pathology
Keywords: Lymph node metastasis Lung squamous cell carcinoma Medical Lung squamous cell carcinoma Tissue microarrays Primary tumor Tumor metastasis Combination of indicators Differentially expressed genes Histological grade
CLC: R734.2
Type: PhD thesis
Year: 2006
Downloads: 130
Quote: 0
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Lung cancer is one of the most common fatal malignancies worldwide. Histopathologically, squamous cell carcinoma (SCC) is the major type of lung cancers. It has been considering that the survival of the patients with lung cancer depends upon staging of the disease. Lymph node status has played an important role in predicting stage and progression of lung cancer.Based on data derived from our previous studies using the high-throughput=approaches, such as comparative genomic hybridization, suppression subtractive hybridization, cDNA microarray and proteomic analyses, 23 genes/proteins (14-3-3beta, 14-3-3sigma, AuroraA, Bit, CathepsinD, CD98, cyclophilinA, Ezrin, Fascin, IQGAP1, Lamininγ2, MMP1, nm23-H1, OLC1, OPN, PSR, RKIP, Sc, TIMP1, TPX2, TrxR1, uPA, and Wcrf) were selected for further investigation. Immunohistochemistry (IHC) analysis was applied to examine the expressive status of these proteins in the tissues derived from SCC of the lung, and then the IHC staining results were manipulated with appropriate statistics methods, to assess the correlation between expression of the proteins and lymphoid metastasis of the SCCs.A set of tissue microarrays (TMAs) was constructed with formalin-fixed and paraffin-embedded tissues (including normal, primary tumor and lymphoid metastatic tumor) collected from a cohort of 319 cases of SCC in the

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CLC: > Medicine, health > Oncology > Respiratory system tumors > Lung tumors
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