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Osteoblasts Induced from Human Marrow Mesenchymal Stem Cells Support Hematopoietic Stem/Progenitor Cells from Umbilical Cord Blood

Author: HuangXiaoBing
Tutor: LiuZuo
School: Sichuan University
Course: Internal Medicine
Keywords: Marrow mesenchymal stem cells Induce Osteoblasts A two-dimensional culture system Hematopoietic stem/progenitor cells Haematopoietic niche Marrow mesenchymal stem cells Osteoblasts Tissue engineering bone with bio-derived materials Osteoblasts electroporation transfection enhanced green fluorescent protein human cord blood CD34+ cells polycation transfection electroporation transfection
CLC: R329.2
Type: PhD thesis
Year: 2006
Downloads: 306
Quote: 0
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Abstract


ObjectiveHematopoietic stem cells niches are subsets of tissues and extracellular subsets that can indefinitely house one or more Hematopoietic stem cells and control their self-renewal and progeny production in vivo. Recent studies prove that osteoblasts and their precursors derived from a common mesenchymal stem cell play a critical role in the creation of a stem cell niche and thereby regulate HSCs maintenance, proliferation, and maturation. It is the demonstration that osteoblast-expressed regulatory components that influence Hematopoietic stem cell function are likely to include cell-cell receptors, soluble and cell surface-associated cytokines, and growth factors. Each of these factors—those known and those yet to be determined—are likely influenced by mechanical, systemic (eg, PTH), and local (eg, BMPs, Ang-1) signals that regulate osteoblastic function. Furthermore, reciprocal cooperation between HSCs and osteoblasts play a profound and central role in the establishment and maintenance of the stem cell niche in the bone marrow. The Osteoblasts' dissertation">Osteoblasts are a heterogeneous population, which includes

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