fenofibrate、 metformin on the body weight、 fat mass、fasting serum glucose、insulin 、 HOMA-IR and MCP-1 levels " />
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Effects of Different Medicine on Body Weight、Fat Mass、Fasting Serum MCP-1 Level of High-Fat Diet Induced Obese Rats

Author: GaoYanYan
Tutor: ZhaoJiaJun
School: Shandong University
Course: Endocrine and metabolic diseases
Keywords: obesity sibutramine fenofibrate metformin MCP-1 rat body composition amylin obesity rats Ghrelin adipocytokine
CLC: R589.2
Type: PhD thesis
Year: 2006
Downloads: 397
Quote: 0
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Abstract


Objective: Our study aimed to observe the effects of sibutramine、rate' dissertation">fenofibrate、 metformin on the body weight、 fat mass、fasting serum glucose、insulin 、 HOMA-IR and MCP-1 levels of high-fat diet induced obese Wistar rats, and to discuss the possible mechanisms of their effects, so as to assess the impacts of different weight-losing medicine on obesity' dissertation">obesity-related inflammatory state and cardiovascular risk factors and provide experimental evidence for pharmacotherapy of obesity.Methods: 49 3-week-age Wistar rats with body weight from 63.7gram to 99.9 gram were randomly divided into two groups: rats of one group received high-fat diet, and those of another group received normal diet. 19 weeks later, we got 27 obese rats (diet-induced obese rat, DIO rat) (mean weight 537.41 ±42.25 gram) ,15 obese resistant rat (diet-induced obese resistant rat, DIO-R rat) (mean weight 418.46±15.73 gram) and 7 normal rats (mean weight 496.43±55.43 gram). Divide all of the 27 DIO rats into five groups randomly according to their body weight. Rats of these five groups were treated with water、sibutramine (10mg/kg)、fenofibrate (83.4 mg/kg)、 metformin (400 mg/kg) individually.All rats went on receiving their foregoing diet. 8 weeks later, all rats were executed. Collect the fasting blood samples and measure the wet visceral fat. Detect the fasting serum MCP-1 and insulin levels by EIA and RIA respectively.

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CLC: > Medicine, health > Internal Medicine > Endocrine diseases and metabolic diseases > Metabolic diseases > Lipodystrophy
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