Dissertation > Excellent graduate degree dissertation topics show

Preparation and formation mechanism of functional polymer magnetic nanoparticles

Author: WuFengQin
Tutor: JiangZuo
School: Nanjing University of Technology and Engineering
Course: Materials Engineering
Keywords: Fe3O4 temperature-sensitive magnetic nanoparticles emulsion polymerization functional
CLC: TB383
Type: Master's thesis
Year: 2012
Downloads: 170
Quote: 2
Read: Download Dissertation

Abstract


Functional magnetic polymer nano-material is an advanced material. It combines the properties of polymer materials, magnetic materials and nano-materials. It has been widely applied in cell separation, targeted cancer therapy, biological and medical field, especially in cancer treatment. Cancer treatment can be divided into chemical drug therapy, radiotherapy, surgery and hyperthermia. The aim of this paper is to prepare a temperature-sensitive magnetic polymer nano-material. This material’s solubility is very good in water as well as its dispersion, content of magnetic matter is high and distribution of particle size is small. Such temperature-sensitive magnetic polymer nano-material is an ideal magnetic targeting drug delivery in cancer treatment. The main research contents are as follows:(1) Fe3O4 magnetic fluid was prepared by chemical precipitation. The Fe3O4 particles were synthesized by chemical precipitation and modified with oleic acid. The resultant particles were then dissolved in octane. This is known as magnetic fluid. The dispersion of Fe3O4 magnetic particles in octane was very good, and there’s no precipitation after a long time.(2) Fe3O4/PS magnetic microspheres were prepared via hybrid emulsion polymerization. In this study, hybrid emulsion polymerization is the improvement of miniemulsion polymerization. The monomers were handled in different ways, but the remaining steps were basically in the same way. The prepared particles’ diameter was reduced from 70nm (one-step miniemulsion method) to 60nm, and the dispersion of particles solution was improved relatively.(3) Fe3O4/PS/PNIPAM magnetic nano-particles were synthesized by two-step soap-free emulsion polymerization. Based on the Fe3O4/PS polymerization technique, temperature-sensitive monomers (such as N-isopropyl acrylamide, N-isopropyl methacrylamide, etc.) were induced to polymerization process to synthesize a kind of temperature-sensitive magnetic material which has a higher critical solution temperature (LCST) (higher than 37℃). The particles’ diameter, dispersion, magnetic material content and saturation magnetization were characterized then.(4) Fe3O4/PNIPAM magnetic nano-particles were synthesized via soap-free emulsion polymerization. As a certain concentration of the PS in the composite material which is used as targeting drug carrier can be produced toxic side effect in organism, on the basis of former research, the PS polymer should be removed from the composite material to reduce the side effect. The preparation process and principle of the temperature-sensitive magnetic polymer composite was studied then.

Related Dissertations

  1. Research and Development of Wear Resistance for Physically Disabled Men Jackets,TS941.2
  2. The Research on the Comprehensive Modification Technology of Rice Protein Enzymatichydrolysis and Graft Copolymerization,TS201.2
  3. Preparation and Properties of Chitosan-based Thermosensitive Composite Hydrogel,R943
  4. Preparation and Characteration of Composite Microspheres with Dual-, Triple- Responsive Properties,O631.3
  5. The Research on the Modification and Functional Properties of Rice Glutelin,TS201.21
  6. Development of Functional Automotive Interior Textiles,TS106.6
  7. Studies on the Influence of Thiol-Functional Ionic Liquids on CdSe Quantum Dots,O649
  8. Complex functions drug-loaded microspheres and in spinal cord injury treatment Application of,R943
  9. Cyclodextrin -modified magnetic nanoparticles synthesis and study drug carrier,TQ460.1
  10. Core-shell polymer microspheres synthesis, modification and application,O631.3
  11. WC / graphene composite electronic structure and electron transport properties,O613.71
  12. Effects of Naloxone on L-type Calcium Channels in Isolated Cardiomyocytes of SD Rat,R614
  13. Theoretical study M_x (M = Cu, Ag, Au) / graphene structure and stability,O613.71
  14. The Study of Conductive Polymer Sound-absorption Film Material,TB383.2
  15. Study on the Preparation, Structure and Properties of Multi-functional Silk Via ATRP Method,TS143
  16. Primary Analysis of the Character of TRBV F&P Gene Family CDR3 in the Peripheral Blood of Mother and Son by Technique of CE&HTS,R392.1
  17. The Research on the Preparation of Temperature/pH-sensitive Copolymer Materials and the Release Behavior of Its Load Paclitaxel,O631.3
  18. Synthesis of Functional Block Copolymer of Polyphosphoester and Their Functionlization,O631.3
  19. Studies on Magnetic Nanocomposite Particles as Drug Carriers for Photodynamic Therapy Agents,TB383.1
  20. A Density Functional Theory Study for Wn C0,± （n=1-6） Clusters,O641.1
  21. A Study for Structure and Properties of OsnN0, ± （n=1-6） Clusters,O641.1

CLC: > Industrial Technology > General industrial technology > Materials science and engineering > Special structural materials
© 2012 www.DissertationTopic.Net  Mobile