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The Studies Biocompatibility of a New Suturelsee Artificial Vascular

Author: Wu
Tutor: WangDianJun
School: Central South University
Course: Surgery
Keywords: New suturelsee artificial vascular Transplant Biocompatibility
CLC: R654.3
Type: Master's thesis
Year: 2012
Downloads: 46
Quote: 0
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Abstract


[Objective] This study will thoracic aortic aneurysm treatment without after suture artificial vascular graft biocompatibility especially blood compatibility of long-term survival of the animal studies, provide a reference for the ultimate realization of the clinical application.[Methods] in pigs as experimental animals in the conditions of tracheal intubation through the left side of the incision, the two ends of the suture artificial vascular grafts in the experimental pigs, and thoracic aorta connection. Implementation of the new artificial vascular graft group animals after the termination of the animal experiments, blood samples, gross anatomical and histological observation. Finally, the new artificial blood vessel surface thrombus distribution evaluation and the use of scanning electron microscope to observe the surface of the fiber membrane cell deposition.[Results] All pigs included in the study in addition to one died of postoperative hemothorax, successfully survive, no new artificial vascular graft dysfunction caused by experimental suspension cases within six months. During the study period, the new artificial vascular graft group red blood cell hematocrit in the study late hematocrit after30minutes minimum,7days after surgery gradually increased since then has fluctuated within the normal range during the whole experiment hematocrit changes statistically significant (P>0.05);WBC count and neutrophil ratio began to rise significantly higher than preoperative level after7days to slowly return to normal, indicating that during the experiment, and postoperative inflammatory response, making the detected the result of higher than normal. There are significant statistical differences (P<0.05). Platelet count after30minutes minimum, during the whole experiment, due to be warfarin after platelet count of control within the normal range, no significant changes in platelet count (P>0.05); IL-2, IL-6the count after surgery began to rise significantly higher than preoperative level after7days decline, but since then has been maintained at higher than normal average high normal levels. There are significant statistical differences.(P<0.05).Terminate the experiment after the gross anatomy and histological observation were not found obvious with the new artificial blood vessel transplant-related organ damage and organizational structure changes, and no thrombosis. The new artificial surface of the blood vessels there is no obvious visible thrombosis. Electron microscopy, the artificial intimal smooth, no thrombus attached to the vascular endothelial cell attachment, partial necrosis, the formation of debris. Immune HE staining results show that vascular anastomosis can be seen the growth of normal endothelial cells; smooth surface of the artificial blood vessel thrombosis, the formation of endothelial cells. [Conclusion] After the optimal design of a new generation of new artificial blood vessel reached the design requirements, can play a support role of the blood vessels in the half-year course of the study, and showed ideal biocompatibility

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CLC: > Medicine, health > Surgery > Of surgery > Cardiovascular and lymphatic system surgery > Vascular
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