Dissertation > Excellent graduate degree dissertation topics show

The Effects of Ischemic Postconditioning on Chaperones in the CA1Neurons Suffered Transient Ischemia and Reperfusion

Author: YangYing
Tutor: LuoYiNan
School: Jilin University
Course: Clinical
Keywords: Ischemic postconditioning Transient cerebral ischemia Chaperone hsp70Chaperone hsp40
CLC: R743.3
Type: Master's thesis
Year: 2013
Downloads: 21
Quote: 0
Read: Download Dissertation


Objective: To investigate the effects of ischemicpostconditioning on the chaperones in the CA1neurons sufferedtransient ischemia and reperfusion.Methods:Transient global ischemia rat model was used.Following different reperfusion period, all the Wistar rats weredivided into ischemia group and ischemic postconditioning group.Each group was divided further into sham-operation group,12hours recovery group,24hours recovery group,48h recoverygorup and72hours recovery group. Differential centrifuge andwestern blotting analysis were used to analyze the quantitativealteration of hsp40and hsp70.Results: HE staining showed that ischemic postconditioningreduced neuronal death induced by transient ischemia andreperfusion. Western blotting analysis showed that the expressionof hsp70was upregulated, and the content of hsp40in CA1neurons was improved by ischemic postconditioning.Conclusion: Ischemic postconditioning could improve thequantity of hsp70and hsp40in the CA1neurons, and reduced neuronal death in the CA1region caused by ischemia andreperfusion.

Related Dissertations

  1. Comparative Proteomics Study on Myocardial Mitochondrial Proteins in Rats Following Ischemic Postconditioning,R614
  2. Neuro Protection and the Optimal Time Window of Ischemic Postconditioning in Rats with Cerebral Ischemia Reperfusion Injury,R651.1
  3. Positive Effects of Ischemic Postconditioning on Cerebral Ischemia/Reperfusion Injury in Rats,R743.3
  4. Experimental Study of the Protective Effect of Mechanical Post-conditioning and Pharmacological Post-conditioning on Acute Ischemia Reperfusion Myocardium,R541.4
  5. Effects of Ischemic Postconditioning on Oxygen Free Radical of the Renal Ischemia Reperfusion in Rats,R692
  6. Effect of Ischemic Postconditioning on Expression of HIF-1α and HO-1 Protein in Rats after Kidney Ischemia Reperfusion Injury,R692
  7. Postconditioning Attenuates Kidney Ischemia Reperfusion Injury via p38 Mitogen-activited Protein Kinase and c-Jun N-terminal Protein Kinase in Rats,R692
  8. The Role of Mitochondrial Permeability Transition Pore (mPTP) on the Ischemic Postconditioning Against Focal Cerebral Ischemia in Rats,R743.3
  9. Protective Mechanism of Osthole Postconditioning Against Acute Myocardial Ischemia/Reperfusion Injury in Rabbits,R285.5
  10. The Protective Effect of Ischemic Postconditioning on Ischemia Reperfusion Injury of Rat Lung,R563
  11. Changes of Apoptosis of Myocardial Cells and Expression of Bcl-2 and Bax of Rats with Myocardial Ischemic Postconditioning,R541
  12. Effects of Ischemic Postconditioning on I/R Myocardial NF-κB and ICAM-1 Expression in Rabbits,R541
  13. Effects of Ischemic Postconditioning on Cmyocardialapoptosis and Expression of Related Gene Protein in Myocardialischemic Reperfusion in Rats,R541
  14. Protective Effect of rhBNP and Ischemia Postcondition on Acute Myocardial Ischemia/reperfusion Injury in Rabbit,R541
  15. Role of Mitochondria in Ischemic Postconditioning-induced Attenuation of Cerebral Ischemia in Diabetic Rats,R587.2
  16. Protective Effects of Postconditioning in Rat Hepatic Ischemia Reperfusion Injury,R657.3
  17. Effect of Ischemic Postconditioning on Bcl-2、Bax Protein Expression in Rat Liver Cells after Ischemic Reperfusion,R614
  18. Ischemic Postconditioning Protects Aged Rat Hearts Against Acute Ischemia/Reperfusion Injury and the Mechanisms,R541
  19. Study of Protective Effect of Post-conditioning on Rat Hepatic Ischemia-Reperfusion Injury,R657.3
  20. Effect of Combination of Ulinastatin, Ischemic Preconditioning and Ischemic Postconditiong on the Renal Ischemi-referfusion Injury in Rats,R692
  21. The Protective Effects of Postconditioning on Cerebral Ischemia/reperfusion Injury in Rat Cerebrum,R741

CLC: > Medicine, health > Neurology and psychiatry > Neurology > Cerebrovascular disease > Acute cerebrovascular disease ( stroke)
© 2012 www.DissertationTopic.Net  Mobile