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Objective : To observe the liver and kidney tonic combined piribedil clinical efficacy of the treatment of advanced Parkinson 's disease . Methods: 60 patients met the inclusion criteria with advanced Parkinson's disease (PD) patients were randomly divided into two groups , the treatment group and the control group of the 30 cases , the two groups in age , gender , disease duration, underlying diseases, symptom scores distribution UPDRS scores fundamental equilibrium , statistical analysis , there was no significant difference ( p lt; 0.05 ) , the two groups were comparable . Treatment the group be Piribedil sustained-release tablets ( initially measured at 50 mg / d , according to the severity of the disease , the weekly increase 50mg, increased to 150mg-250mg / d, to achieve an effective dose to maintain the dose ) orally , at the same time be liver and kidney tonic prescription oral . Basic side : Rehmannia 24g, dogwood 12g , Tianma 10g, Uncaria 10g , Chinese yam and medicine 12g , Alisma 9g moutan 9g , Poria 9g the Ophiopogon 9g , Schisandra 6g, France Pinellia 15g orange 15g Amomum 10g If insomnia is Canadian Health keel 30g , raw oysters 30g . , Zhigancao 6g ; constipation is plus citrus aurantium 12g , rhubarb 6g ; if tremor obvious plus silkworm 12g, Scorpio 3g, Chan Yi 6g; Shuijianbi day one in three doses , each 200ml of warm clothes . Maintain the dose ) in the control group, only to be piribedil oral sustained-release tablets ( initially measured at 50 mg / d , according to the severity of the disease , the weekly increase in 50mg, increased from 150 mg to 250 mg / d to achieve an effective dose . The course of treatment was 6 months. Unified PD Rating Scale (UPDRS) score before treatment and after treatment , all patients are symptom scores and Hoehn \u0026 Yahr stage , these are professional neurologist evaluated . Results: the treatment group and the control group after treatment UPDRS scores , symptom scores and Hoehn Yahr staging, the ratings were lower than before treatment ( p lt; 0.05 ) , but the scores of the treatment group was significantly lower than the control group , and the treatment the group's total efficiency than the control group ( p lt; 0.05 ) . Conclusion: The treatment of advanced Parkinson 's disease , a significant effect of liver and kidney tonic combined piribedil , and can reduce the the piribedil adverse reaction , it is worth to use in clinical practice .
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