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Objective atherosclerosis rat model to investigate the 5 - lipoxygenase / leukotriene pathway in atherosclerosis , the expression of the significance and mechanism . 75 ( 1 ) adult male SD rats were randomly divided into 5 groups , 15 in each group were : group A : normal control group ; B group : the atherosclerosis group ; C group : Montelukast Sodium 1mg group ; group D : montelukast Sodium 3mg group ; group E : simvastatin group . ② normal control group continued normal diet , atherosclerosis group , Montelukast Sodium 1mg group , Montelukast Sodium 3mg group , simvastatin group, high fat diet for 14 weeks feeding atherosclerosis model ; ③ montelukast Sodium 1mg group , montelukast Sodium 3mg group , simvastatin group and then were given montelukast sodium , simvastatin orally intervention for 4 weeks, 18 rats were killed over the weekend , five groups were blood test blood lipids , 5 - lipoxygenase , leukotriene B4 , leukotriene C4 level separation of the abdominal aorta , part of HE staining and transmission electron microscopy observation endometrial pathology , part of homogenized , ELISA assay abdominal aorta 5 - lipoxygenase , leukotriene B4, leukotriene C4 content . Results atherosclerosis group Montelukast Sodium 1mg group , Montelukast Sodium 3mg group lipids was significantly higher than the normal control group (P lt; 0.01), simvastatin group lipids than atherosclerosis group was significantly lower (P lt; 0.01); atherosclerosis group montelukast Sodium 1mg group , simvastatin group 5 - lipoxygenase , leukotriene B4, C4 content than the normal control group increased ( P lt ; 0.05) ; montelukast sodium 3mg group of leukotriene C4 content of atherosclerosis was reduced ( P lt; 0.05 ) . The atherosclerosis group intimal hyperplasia is obvious , its comparison , no significant difference between montelukast sodium 1mg group of montelukast the 3mg group, and thinning of the intima-media thickness of the simvastatin group . Conclusion 5 - lipoxygenase , leukotriene B4, leukotriene C4 expression in rat blood and aortic atherosclerosis are abnormally high levels ; Montelukast Sodium reduce the content of leukotriene C4 with simvastatin the same as having a role in anti- atherosclerosis , but no role in lowering blood lipids ; 5 - lipoxygenase / leukotriene pathway may be a new target for blocking atherosclerosis .
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