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Objective: Rheumatoid arthritis (rheumatoid arthritis, RA) is a kind of chronic, progressive, aggressive arthritis as the main manifestation of systemic autoimmune disease characterized by persistent, symmetry, progressive and destructive small joints lesions as the main feature, the performance of peripheral joint persistent synovitis, synovial hyperplasia, inflammatory cell infiltration, pannus formation, thereby giving rise to progressive cartilage and bone destruction, resulting in joint deformity and loss of function, eventually leading to different degree of disability. The disease can occur in any age, and the distribution is extremely broad, and the duration of persistent, recurrent, serious threat to people's health. Its etiology and pathogenesis is not clear, there are still no effective treatment. Western medicine has significant long-term side effects, and the patient is not easy to adhere to. Chinese medicine treatment of RA has a long history, clinical studies have shown that the process of Chinese medicine in the treatment of RA have anti-inflammatory analgesic, improve circulation, immune suppression and immunomodulatory effects and adverse reactions, patients are easy to adhere to, in recent years widely in clinical medicine applications, has made some achievements. Through this research intends to observe the treatment of rheumatoid arthritis patients before and after blood microcirculation indicators of change, on the western therapy were analyzed and compared in order to optimize the treatment of this disease and provide evidence. But also to further explore the process of Chinese medicine in the treatment of RA in the mechanism for the clinical treatment provided a new way. Methods: 81 patients diagnosed were randomly divided into two groups: control group: the western medicine group was the control group. Patients were treated with leflunomide tablets (trade name: love, if China, 10mg / tablets, Suzhou Long - XINKAI Pharmaceutical Co., Zhunzi: H20000550), 10mg / times, 2 times / day; loxoprofen sodium tablets (trade name: Le Pine, 60mg / tablets, Shanghai Sankyo Co., Zhunzi: H20030769), 60mg / times, 2 times / day treatment groups: traditional Chinese medicine and western medicine treatment group. In the control group on the basis of medication, plus service self blood Qufeng Chinese Herbs (TCM formulations were used Chinese Medicine Hospital of Wuhan City \juice, 200m1 / time, 2 times / day. 1 month course of treatment, observing a course of treatment. Applications were enhanced power Doppler imaging in patients with rheumatoid arthritis were observed before and after treatment of finger pulp artery peak systolic velocity (PSV), peak diastolic velocity (EDV) and vascular resistance (RI) parameters, blood rheology and clinical symptoms related indicators change after the end of the observation efficacy evaluation. Results: a total efficiency of the comparison: the treatment group, the total effective rate was 90.24%, significantly higher than 75.00% (P lt; 0.05). (2) Comparison of clinical symptoms and signs: the treatment group significantly improved clinical symptoms and signs, joint pain index, swelling index, dysfunction index decreased, duration of morning stiffness was significantly shorter, compared with the control group improved more significantly. 3 detection index improvement: the treatment group of the pulp microcirculation indicators PSV, EDV, RI, hemorheology erythrocyte sedimentation rate, whole blood viscosity, plasma viscosity, hematocrit, platelet adhesion rate and erythrocyte electrophoresis, compared with the control group were a significant improvement. 4 Safety Observation: two groups of patients during and after treatment were not significant cytopenia, liver and kidney dysfunction, gastrointestinal discomfort and other adverse reactions. Conclusion: TCM blood Qufeng France combined with Western leflunomide tablets, loxoprofen sodium tablets can significantly improve in those suffering from rheumatoid arthritis joint pain, joint swelling, joint dysfunction and other clinical symptoms and signs, can significantly lower ESR, whole blood viscosity, plasma viscosity, hematocrit, platelet adhesion rate and erythrocyte electrophoresis and other indicators, can significantly improve patient pulp artery peak systolic velocity and diastolic peak velocity, reducing vascular resistance parameters. These studies have shown that blood Qufeng method combined with leflunomide tablets, loxoprofen sodium tablets can improve microcirculation in patients with rheumatoid arthritis, rheumatoid arthritis is effective and safe to use, and more than Western medicine alone a competitive advantage, it is worth drawing the majority of clinicians and applications.
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