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Temperature Induced Self-assembly and Self-crosslinking Prepared Biocompatible and Bioredue

Author: HanLiFen
Tutor: YouYeZi
School: University of Science and Technology of China
Course: Polymer Chemistry and Physics
Keywords: core-shell nanoparticles hollow nanocapsules Michael addition self-assembly self-crosslinking technologies
CLC: TQ460.1
Type: Master's thesis
Year: 2013
Downloads: 2
Quote: 0
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Abstract


In recent years, the stimuli responsive and biocompatible nanocarriers have aroused many researchers’ interests in the field of controlled release of drugs. The stimuli responsiveness includes temperature, reduction, enzyme, pH responsiveness etc, of which the enzymatic responsiveness is the one having the most extensive study. The stimuli-responsive carriers can release drugs at specified location with appropriate dose, thus avoiding the damages to biometric normal tissue. An ideal drug carrier should not only have the stimuli-responsive properties, but also possess good biocompatibility. Accordingly, much attention of research is paid to designed different types of carriers. In this paper, we will introduce two different kinds of drug carriers.Part Ⅰ:A new type of hyperbranched polymer which has good temperature sensitivity and biocompatibility was synthesized by Michael addition method. The methods for most of hyperbranched polymers are as following:self-polycondensation, ATRP, RAFT, ring-opening polymerization and proton transfer polymerization. However, Michael addition polymerization method is one of the synthesis methods with most research value since the Michael addition method is provided with mild reaction conditions, a large number of functional groups, a wide variety of polymerizable monomers, high conversion rate and satisfactory reaction rate. By Michael addition, the temperature-sensitive hyperbranched polymer had good biocompatibility, and its temperature sensitivity can be adjusted through the hydrophilic and hydrophobic monomer molar ratio.Part Ⅱ:The temperature-induced self-assembly and self-crosslinking technologies were applied to the preparation of core-shell nanoparticles. This new method is very simple, and we just need to dissolve the well-synthesized polymer in the dispersed water, followed by heating allowing them to perform self-assembly and self-crosslinking, finally formed the core-shell structure required. The thickness of the shell can simply be adjusted by changing the content of the polymer. The core-shell nanoparticles by this method have good biocompatibility and stability. In addition, we can prepare the temperature-sensitive and biodegradable nanocapsules through HF etching the core.

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CLC: > Industrial Technology > Chemical Industry > Pharmaceutical chemical industry > General issues > Basic theory
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