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Curative Effect Observationin of Nei Yi-ting Formula in Treating Recurrent Ovarian Endometriosis

Author: JiLi
Tutor: ShiYanPing
School: Nanjing University of Traditional Chinese Medicine
Course: Chinese Gynecology
Keywords: Ovarian endometriosis Recurrence after conservative operation Nei Yi-tingformula T-lymphocyte subsets
CLC: R271.9
Type: Master's thesis
Year: 2013
Downloads: 25
Quote: 0
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Abstract


Objectives endometriosis (EMS) is a kind of gynecological disease that the active endometrial tissues appear in parts other than the uterus and bleed periodically. Under the effect of ovarian hormones, a cyst is formed when Ectopic endometrium bleeds Periodically, called ovarian endometriosis (OEM, Also called ovarian chocolate cyst).EMS has benign features on the pathological and malignant characteristics in biology. That is With the features of invasion, metastasis and recurrence. Although the treatments vary, there are Recurrence. Prevention and treatment of OEM recurrence after conservative surgery are one of the gynecological problems and important research topics.By observing the change of clinical symptoms of TCM, serum CA125, the size of ovarian cysts tested by B-mode ultrasound, t-lymphocyte subsets (CD4, CD8, CD4/CD8), We explore therapeutic effect and mechanism of Nei Yi-ting formula on recurrent OEM and Observe the correlation of T-lymphocytes and recurrent OEM.Methods Forty-five patients of OEM recurrence after conservative surgery divide into treatment and control groups according to the medication. The treatment group of23cases take Nei Yi-ting formula. The control group of22cases take Da Huang Zhe Chong pill. Two groups are administrated3months continuously. We observe the change of TCM syndrome integral, serum CA125, the size of ovarian cysts tested by B-mode ultrasound, T-lymphocyte subsets (CD4, CD8, CD4/CD8).Results After treatment,the total effective rates of the treatment group and control group are respectively78.26%and63.64%. Comparative difference of the two groups is statistically significant((P<0.05). The overall effective rates of TCM syndrome of the Treatment group and control group are respectively86.96%and72.73%. Comparative difference of the two groups is statistically significant((P<0.05). After treatment, maximum diameter of ovarian cysts of the two groups all reduce.Differences are statistically significant(P<0.05). Comparative difference between the two groups After treatment is no statistically (P>0.05). Compared with before treatment,the CA125of the treatment group declines, difference is statistically significant(P<0.05). The CA125of the Control group before and after treatment has no apparent change(P>0.05). The treatment group is better than the control group and difference is statistically significant(P<0.05). Before treatment, CD4is in the normal range but on the low. CD4/CD8ratio declines obviously and CD8elevates clearly. CD4and CD4/CD8ratio of the treatment group rebound and CD8decreases. Both of the differences are statistically significant (P<0.05). Comparative difference of the indicators of the control group before and after treatment is no Statistically significant (P>0.05).The improvements of CD4andCD4/CD8ratio of the treatment group are better than those of the control group.Both of the differences are statistically significant (P<0.05). CD8difference of the two groups after treatment is no statistically significant (P>0.05).Conclusion The therapeutic effect of Nei Yi-ting formula on recurrent OEM is exact. Nei Yi-ting formula can obviously alleviate clinical symptoms, reduce cysts and the level of serum CA125, improve cellular immune function through increasing CD4and CD4/CD8ratio while reducing CD8in peripheral blood.

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CLC: > Medicine, health > Chinese Medicine > Traditional Chinese Medicine Obstetrics and Gynecology > Modern medicine, obstetrics and gynecology disease
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