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Stabilized chlorine dioxide release gel preparation and efficacy studies

Author: HuChaoYun
Tutor: BiXiaoPing
School: Shanxi Medical
Course: Pharmaceutical Analysis
Keywords: Chlorine dioxide Gel Preparation Efficacy
CLC: R96
Type: Master's thesis
Year: 2010
Downloads: 129
Quote: 0
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Abstract


Objective: In this paper, the stability of chlorine dioxide as a model drug, aqueous gel matrix as the main base, preparing topical formulations - stable chlorine dioxide release gel, chlorine dioxide be released slowly extended action effect, reducing the number of drugs for the prevention and treatment of various wound surface infection. Methods: created by UV spectrophotometry, high performance liquid chromatography, ion-pair on the stability of chlorine dioxide and chlorine dioxide gel assay method. UV spectrophotometry release chlorine dioxide gel in vitro release were measured; blank gel matrix screening process, respectively, of the main matrix acid chitosan, sodium carboxymethyl cellulose and Carbopol 940 the system filter, on this basis, in order to release as an indicator, the gelling agent selected optimal formulation; chlorine dioxide release and gel stability for the quality evaluation, performance and stability in vitro release study; was also carried out with E. coli, Staphylococcus aureus, Bacillus subtilis as the representative of the bacteriostatic and bactericidal properties of visits, and rabbit skin wounds as a model for the prevention and treatment of wound infection effect inspection. Results: UV spectrophotometry at a wavelength of 260nm, the sustained-release gel for the determination of stable chlorine dioxide, the average recovery was 99.20%, RSD was 1.07%, results are accurate and reliable. At the same time, the paper also explores the use of oxidation with hydrogen tetrabutylammonium ion-pairing reagents for the proportion of methanol - water as mobile phase ion-pair reversed-phase high-performance liquid chromatography gel stabilized chlorine dioxide release Determination of chlorine content, the average recovery was 99.36%, RSD was 1.24%, the result is accurate, this method with UV spectrophotometry consistent with the results. In prescribing the screening process, chlorine dioxide release of acid-soluble chitosan gel stability remains to be further research and improvement; sodium carboxymethyl cellulose and Carbopol 940 as the main mixing matrix chlorine dioxide sustained-release gel, all of which are in accordance with requirements, the main prescription comprising: Stability of chlorine dioxide, sodium carboxymethyl cellulose, carbomer 940, acetic acid, glycerol and the like. In efficacy trials, the stability of the base mixture of chlorine dioxide release gel of E. coli and Bacillus subtilis minimum inhibitory concentration was 74.07mg / L, the minimum inhibitory concentration of Staphylococcus 9.26mg / L; Escherichia coli and Staphylococcus aureus minimum bactericidal concentration of 148.14mg / L. Release chlorine dioxide gel on the wound surface in rabbits back effect of treatment with mupirocin ointment basically the same. Conclusion: UV spectrophotometry on the stability of chlorine dioxide and its gel content determination method is simple, low cost; ion-pair reversed phase high performance liquid chromatography and gel content of chlorine dioxide measurement results accurate, simple operation, high sensitivity; prepared sodium carboxymethyl cellulose and Carbopol 940 as the main mixing matrix release chlorine dioxide gel quality meets the 2005 version of \Fabricated using two yuan package, one, chlorine dioxide gel component A, secondly, activator gel component B, mixing before use. Release chlorine dioxide gel with broad-spectrum antimicrobial activity; right back to rabbit as a model of trauma treatment satisfaction. As a topical formulation to achieve the prevention and treatment of various wound surface infection.

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CLC: > Medicine, health > Pharmacy > Pharmacology
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