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Objective: To assess Stereotactic Gamma Knife treatment of pituitary tumors in patients with visual function changes, and explore the impact of changes in visual function in patients with prognostic factors. Methods: A retrospective analysis of three different Gamma Knife Center OUR the rotary Gamma Knife treatment clinical data of 116 cases of pituitary adenomas, of which 45 received Gamma Knife treatment neurosurgery 71 cases Gamma Knife as the first treatment. Patients underwent preoperative visual acuity, field of vision, slit lamp, fundus examination to rule out refractive media opacity, macular and other retinal diseases, regular reexamination after visual acuity vision observed with MRI clinical efficacy, statistical analysis of Gamma Knife treatment of pituitary adenoma patients visual function changes with preoperative depending on function level, tumor size, gender, age, pathological type, whether the invasion of the cavernous sinus, marginal dose relationship. Results: Gamma Knife preoperative visual dysfunction in 76 patients, univariate analysis (chi-square test) results show that depending on the dysfunction in patients with pituitary tumors preoperative tumor volume (p = 0.031), and whether the surgery (p = 0.042) and age (p = 0.04) factors related to, regardless of the pathological type (p = 0.689) and gender (p = 0.996); logistic multi-factor analysis found that the tumor volume, age is an independent predictor of visual dysfunction in patients with pituitary tumors factors . The fundus changes most primary optic atrophy (72 cases). 2 in all cases a mean follow-up of 51.5 months, visual acuity vision returned to normal in 36 cases, the cure rate was 47.1%; visual function has been restored in 45 patients (59.4%). Gamma Knife treatment inhibited tumor growth, and 84 patients with tumor shrinkage, effective control%; 13 cases (14.4%) hypopituitarism. Gamma knife radiosurgery for pituitary adenoma prognosis of different edge dose comparison, χ 2 = 8.04, P = 0.018, significant; preoperative visual acuity level is greater than 0.5, the prognosis comparison, χ 2 = 11.35, P = 0.001, there statistically significant; prognosis of the tumor volume comparison, χ2 = 6.24, P = 0.028, statistically significant; whether the invasion of the cavernous sinus prognosis compare χ2 = 7.94, P = 0.005, statistically significant. Comparison of the prognosis of different ages, χ2 = 4.09, P = 0.03, statistically significant. Different gender, pathological type of prognosis compare P1 = 0.14, P2 = 0.07, not statistically significant. Conclusion: 1. Gamma knife is a safe and effective treatment for pituitary adenoma; 2. Depending on the level of functioning in the preoperative tumor volume, and whether the invasion of the cavernous sinus, whether surgery, age-related, has nothing to do with gender, pathological type 3 surgery before the level of visual function, tumor volume, invasion of the cavernous sinus, age, peripheral dose significantly affect prognosis; no significant correlation between the histological type, gender and efficacy.
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