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The resveratrol separation pilot

Author: WangFangYuan
Tutor: FanDaiZuo
School: Northwestern University
Course: Chemical Engineering
Keywords: enzymatic treatment resveratrol emodin extraction process pilot scale Polygonum Cuspidatum Sieb. et Zucc
CLC: S567.239
Type: Master's thesis
Year: 2009
Downloads: 46
Quote: 0
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Abstract


Based on a large number of modern research, resveratrol(Res) has important pharmacological action including the anti-cancer, antineoplastic ,antioxidant, anti-inflammatory and anti-heart brain blood vessel disease. Therefore, resveratrol will surely has a broad application prospect.The resveratrol content in polygonum cuspidatum is the highest among all the studied plant species according to known papers. Besides resveratrol and polygonin, polygonum cuspidatum contains more ngredients such as emodin. It is necessary to improve the traditional extraction technique with lower extraction efficiency and higher production.Efficient analytical methods to analyze resveratrol with TLC and HPLC were set up. C18 column(4.6×150mm) was used with a mixture of acetonitrile : water (28 : 72 ,V/ V) as mobile phase, with a flow rate of 1mL/ min and the UV detection wavelength was 305 nm. Determined the resveratrol contents in Polygonum cuspidatum from different habitats: hunan>henna>hebei>shanxi>gansu.The research in the laboratory obtained the optimized process conditions of separating resveratrol from Polygonum cuspidatum. The purity of resveratrol prepared according to this method was above 98.00%,and the yield is more than 75%.Pilot-scale test result obtained the optimized process conditions of separating resveratrol from Polygonum cuspidatum. The purity of resveratrol and emodin prepared according to this method was above 98.2%.

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