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Study and Determination on Voltammetric Behavior of Valaciclovir Hydrochloride and Indometacin and Several Drugs

Author: LinXiaoHua
Tutor: WangGuiFen
School: Yanbian University
Course: Analytical Chemistry
Keywords: valaciclovir hydrochloride famciclovir dextromethorphan hydrobromide nonsteroidal antiinflammatory drugs voltammetry
CLC: R927
Type: Master's thesis
Year: 2009
Downloads: 16
Quote: 0
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Abstract


Drug analysis is an important branch of analytical chemistry, it is an important means to ensure drug safety, and it is closely related with people’s health. Each analysis method has its own advantages in drug analysis, the electrochemical method becomes an important analytical method of drug analysis, because of its high sensitivity, wide dynamic range, simple and fast operation. In this paper,we studied and determined the valaciclovir hydrochloride and several drugs from the chemically modified electrode, the interaction of drug and serum albumin as well as the simultaneous determination of drugs by cyclic voltammetry and differential pulse stripping voltammetry.The main researches were summarized as follows:1.The voltammetric behavior of indometacin and dextromethorphan hydrobromide at glass carbon electrodes were separately studied by electrochemical method.We finded the best experimental conditions and determined the recovery experiments and the determination of the actual samples of the two drugs with the standard addition method, the determination results were satisfactory.2.In the pH=3.0 Britton-Robinson（B-R） buffer solution,we studied the simultaneous determination for the voltammetric behavior of the two nonsteroidal antiinflammatory drugs of indometacin and naproxen at a glass carbon electrode. The linear range of indometacin is 4.0×10-6～1.2×10-4 mol/L and the detection limit is 7.2×10-7 mol/L. The linear range of naproxen is 1.0×10-5～1.6×10-4 mol/L, and the detection limit is 5.6×10-6 mol/L.We chosed the best experimental conditions to ensure the peak of indometacin and naproxen can be completely separated. The analysis method can be used for the simultaneous determination of drug content in the coexistence system of the two drugs, the determination time is saved, it is a fast and accurate analysis method.3.The electrochemical behavior of valaciclovir hydrochloride on the multiwalled carbon nanotubes-Nafion modified electrode was investigated. The oxidation peak current of valaciclovir hydrochloride increased remarkably at a MWNTs-Nafion modified glassy carbon electrode. There is a good linear relationship between the peak current and valaciclovir hydrochloride concentration in the range of 4.0×10-7～1.0×10-5 mol/L,the detection limit is 1 .5×10-7 mol/L. Using this method to detect recovery of valaciclovir hydrochloride tablets,the result is from 96.3% to 100.4%. This method is a sensitive, simple, rapid, cheap method to determine valaciclovir hydrochloride. 4.The electrochemical property of famciclovir was studied by cyclic voltammetry at a polybromocresol green modified electrode.The results show that the oxidation peak current of famciclovir increased remarkably in the pH=4.0 HAC-NaAC buffer solution, the oxidation peak potential is at +1.24V. There is a good linear relationship between the peak current and famciclovir concentration in the range of 1.0×10-6～1.0×10-4mol/L, the detection limit is 2.3×10-7mol/L, it reduces more than twice than the detection limit 5.2×10-7 mol/L which has been determined in NaOH-modified glassy carbon electrode. So the method improves the detection sensitivity.5.We studied the voltammetric behavior of the interaction of dextromethorphan hydrobromide and bovine serum albumin. The experimental results show that the oxidation peak current of dextromethorphan hydrobromide increased remarkably in the pH=7.5 Britton-Robinson（B-R） buffer solution, the oxidation peak potential is at +0.92V. We added a certain amount of BSA in the buffer solution, the result was that oxidation peak potential was almost unchanged while the peak current was reduced.There is a linear relationship between the reduce values of the peak current and the a certain amount of BSA, so it can be used for the electrochemical determination of BSA, it can provide electrochemical information to the research of the effect of drug in the organisms.

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CLC: > Medicine, health > Pharmacy > Pharmacopoeia Codex ( formulary ),drug identification > Drug identification
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