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Influence of Different Doses of Peribulbar Anaesthesia on Rabbit Electroretinography

Author: WangXiangLi
Tutor: ZhangWenFang;LuJianHua
School: Lanzhou University
Course: Ophthalmology
Keywords: electrophysiology local anesthetics peribulbar anesthesia rabbit
CLC: R77
Type: Master's thesis
Year: 2009
Downloads: 6
Quote: 0
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Object Test the influence of different doses of peribulbar anesthesia on rabbit electrophysiology.Methods Health rabbits were assigned to three groups and 6 rabbits for each group. Local anesthetics were injected peribulbarly into right eye ,and the left eye of each rabbit received the same doses of 0.9%NS as a control. With RETIport32-scan system and contact lens electrode, we recorded the latency time and wave amplitudes of the scotopic electroretinograph(scot-ERG), Max response ,oscillatory potentials(Ops), photopic electroretinograph,30Hz flicker response in different time point. Dark adaptation for 20 minutes before every observation.Result Different doses of local anesthetics affected on the latency and amplitude of a and b wave that shown a decreasing trend. A and b latency decreasing of Rod at 30m or 1h are obvious, 1.5ml and 1.0ml groups have statistical differences; obviously at 5m or 30m for Max-response, 1.5ml and 1.0ml groups significant differences; photopic-cone and 30Hz flicker response has the same trend , but p>0.05, no statistical significance. A and b amplitude scotopic-Rod and Max-response and Ops O2 was a downward trend especially at 1h or 1.5 hours, 1.5ml and 1.0ml groups have statistical significant; for photopic-cone a wave( 1.5ml group)and b wave(1.5ml group and 1.0ml group) amplitudes has statistically significant difference ;30Hz flicker response amplitude changes nostatistical difference. In 2 hours , a and b amplitudes still have not recovered. Different doses of the control eyes, a and b amplitudes alsohas a slight downward trend.Conclusion Peribulbar anesthesia can cause changes in ERG ofrabbit. These changes related with the doses. Different doses of localanesthetics mainly cause ERG change in dark adaptation, secondlyphotopic ERG. The role of the drug are probably the main reason for theimpact.

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