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Objective:To reveal differences in three-dimensional reconstructions of multi-slice spiral CT between pulmonary neoplastic lesions and non-neoplastic lesions, which showed focal ground-glass opacity or ground-glass opacity predominance. Methods:A total of 48 focal areas of ground-glass opacity and ground-glass opacity predominance, consisting of 36 neoplastic and 12 non-neoplastic lesions, were assessed retrospectively regarding their findings of three-dimensional reconstructions of multi-slice spiral CT, all of them were confirmed by pathology or clinical follow-up. The size, three-dimensional ratio, shape(round to ovoid, polygonal to irregular), margin(spiculation, lobulation, spine-like process), contour (well-defined, ill-defined), internal characteristics (solid portion, internal air density, air bronchogram, other air-containing space) and adjacent structural change (pleural indentation, vascular convergence) of the lesions were estimated according to pathology. Differences between neoplastic lesions and non-neoplastic lesions were analyzed by using the chi-square test, Fisher’s exact test or Mann-Whitney U test. A two-sided value of P<0.05 was used as criterion to indicate a statistically significant difference. Results:48 fGGO included 15 pure areas of ground-glass opacity and 33 mixed ones. In terms clinical data, size, spiculation, spine-like process, other air-containing space, pleural indentation, there were no statistical differences between neoplastic and non-neoplastic fGGO. MSCT findings of three-dimensional ratio, round to ovoid, polygonal to irregular, lobulation, well-defined and ill-defined contour, solid portion, internal air density, air bronchogram, vascular convergence were significantly different between neoplastic and non-neoplastic fGGO. Conclusion: Three-dimensional reconstructions MSCT is helpful to make timely diagnosis between pulmonary neoplastic lesions and non-neoplastic lesions, which showed focal ground-glass opacity or ground-glass opacity predominance. Three-dimensional reconstructions MSCT feature of three-dimensonal ratio approach to 1-1.24, round to ovoid shape, lobulation, well-defined contour, solid portion, internal air density, air bronchogram, vascular convergence were very important for neoplastic diagnosis. Three-dimensional ratios equal to or greater than 1.5, polygonal to irregular shape and ill-defined contour were important for non-neoplastic diagnosis.
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