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Objective: To observe the relationship between different TCM dialectical type and associate with sex hormones and risk factors of cardiovascular disease, provide the evidence for the early intervention and treatment as different dialectical type in perimenopausal women of hypertension. then provide objective index for TCM dialectical type in perimenopausal women of hypertension. Methods: 820 cases who joined the healthy physical examination were included in the study and were divided into two groups according to perimenopausal syndrome diagnostic criteria incorporated, of 45～55 years old Han women, and on the basis of Chinese hypertension preventing and controlling guide 2005, divided into hypertension group and healthy control group, together collected 180 cases in perimenopausal patients with hypertension, then according to the Guideline about clinical research of new traditional Chinese drugs, combined with the research of syndrome differentiation was divided into four groups; yin deficiency and internal dryness, stagnation of phlegm, heart lienal two deficiency, yin and yang two deficiency, from perimenopausal healthy control group randomly selected 30 cases as control group. All cases were recorded of sex hormone, blood lipids, blood glucose, high sensitivity C reactive protein, body mass index, and do statistical analysis. Results: To the single factor analysis of variance, the results showed; yin deficiency and internal dryness type of E2 lower than liver stagnation and phlegm, heart lienal two deficiency, yin and Yang two deficiency and the control group E2; Yin deficiency and internal dryness, stagnation of phlegm, heart lienal two deficiency, yin and yang two deficiency type FSH, PRO, TG, TC, LDLC, BMI, hs-CRP higher than that of the control group (P<0.05); Yin deficiency and internal dryness, stagnation of phlegm, heart lienal two deficiency, yin and yang two deficiency type HDLC lower than the control group; liver stagnation and phlegm type TG higher than Yin deficiency and internal dryness, heart lienal two deficiency, yin and yang two deficiency type and the control group; liver stagnation and phlegm type BMI higher than Yin deficiency and internal dryness, heart lienal two deficiency, yin and yang two deficiency type BMI and the control group; Yin and yang two deficiency type fasting blood glucose higher than Yin deficiency and internal dryness, stagnation of phlegm, heart and spleen two deficiency type, the control group had statistical significance (P<0.05). According to the Logistic regression analysis, the results show; E2 (OR=7.703, P=0.004) is the most significant independent risk factor related of hypertension in perimenopausal women, TC is protective factor in perimenopausal women with hypertension. HDLC (OR=9.562, P=0.004), TG (OR=4.484, P=0.048), BMI (OR=4.346, P=0.034), are the significant risk factors of hypertension in perimenopausal women with accumulation of stagnation of phlegm type, LDLC (OR=8.605, P=0.002), FPG (OR=4.105, P=0.04) are the significant risk factors of hypertension in perimenopausal women with the Yin and Yang two deficiency, TC (OR=8.655, P=0.002), hs-CRP (OR=4.165, P=0.04) are the significant risk factors of hypertension in perimenopausal women with is the heart lienal two empty type climacteric hypertension independent risk factors. Conclusion:E2 is the most significant independent risk factor related of hypertension in perimenopausal women, HDLC, TG, BMI are the significant risk factors of hypertension in perimenopausal women with accumulation of stagnation of phlegm type, LDLC, FPG are the significant risk factors of hypertension in perimenopausal women with the Yin and Yang two deficiency, TC, hs-CRP are the significant risk factors of hypertension in perimenopausal women with is the heart lienal two empty type climacteric hypertension independent risk factors.These objective index can provide evidence for TCM dialectical type of hypertension in perimenopausal women, and helpful to objectification and quantification of TCM dialectical type.
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